DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp2 and FOXI1

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_036320.2	Gene:	FOXI1 / 2299	HGNCID:	3815	Length:	378	Species:	Homo sapiens

Alignment Length:	286	Identity:	98/286 - (34%)
Similarity:	126/286 - (44%)	Gaps:	90/286 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 KPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSLNKCFVKVPRH 244
            :|||||:|||.|||..:.:|||||:.||:|:..|.|:|..:|.|||||||||||||.||.||||.
Human   123 RPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRD 187

  Fly   245 YDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTT--AASRSRLAAFKRSLIGPMFPGLAAYPQFGQ 307
            .|||||||||.|||:.|.:|..|:..:.|:|.:  ::|.:.||..|.....|:.......||
Human   188 EDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPVDSPKTTEPQ--- 249

  Fly   308 FLTYPPTAPSLLASMYQRYNPFAPKGGPGHPGLPPGLPGLPGPPGPQGPPGPPPPPFVAPPTSSE 372
                     .:|                  .|..||  |....|..:    |.|||..||..:|.
Human   250 ---------DIL------------------DGASPG--GTTSSPEKR----PSPPPSGAPCLNSF 281

  Fly   373 LYQRLQYQQLLHQHAAAAALAAHQRQLSVAAASAASQPPPTHHHPHLAVGQAPLSPGGDSPGPSP 437
            |.....|                     |:..|      ||.|         ||.    :||.||
Human   282 LSSMTAY---------------------VSGGS------PTSH---------PLV----TPGLSP 306

  Fly   438 QPLHK------------PVTVVSRNS 451
            :|..|            |:|.:|.:|
Human   307 EPSDKTGQNSLTFNSFSPLTNLSNHS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	55/84 (65%)
FOXI1	NP_036320.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		FH	123..211	CDD:214627	56/87 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..278		22/105 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820