Protein Alignment slp2 and FOXD4

DIOPT Version :10

• Sequence 1: NP_476834.1
• Gene: slp2 / 33608
• FlyBaseID: FBgn0004567
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_997188.2
• Gene: FOXD4 / 2298
• HGNCID: 3805
• Length: 439
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 125/412 - (30%)
• Similarity: 158/412 - (38%)
• Gaps: 117/412 - (28%)

  Fly    44 LNLTNLMKMARTPH--LKSSFSINSILPETVEHHDEDEEEDVEKKSPAKFPPNHNNNNLNTTNWG 106
            :||....::..||.  |:.|...:..:....|..||||||...:    :|........|....||
Human     1 MNLPRAERLRSTPQRSLRDSDGEDGKIDVLGEEEDEDEEEAASQ----QFLEQSLQPGLQVARWG 61

  Fly   107 S---PEDH-EAESDPESDLDVTSMSPAPVANPNESDPDEVDEEFVEEDIECDGETTDGDAENKSN 167
            .   |.:| |....|                   |||.|...||                .....
Human    62 GVALPREHIEGGGGP-------------------SDPSEFGTEF----------------RAPPR 91

  Fly   168 DGKPVKDKKGNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNL 232
            .....:|.:...|||.||.|||.|||.||..|||||:||..:|....||||.....|||||||||
Human    92 SAAASEDARQPAKPPSSYIALITMAILQSPHKRLTLSGICAFISDRFPYYRRKFPAWQNSIRHNL 156

  Fly   233 SLNKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRLAAFKRSLIGPMFP 297
            |||.||||:||....|||||||.|||:::|:|..||..:.|:|           |:|.
Human   157 SLNDCFVKIPREPGRPGKGNYWSLDPASQDMFDNGSFLRRRKR-----------FQRH------- 203

  Fly   298 GLAAYPQFGQFLTYPPTAPSLLASMYQRYNPFAPKGGPGHPGLPPGLPGLPGP-PGPQGPPGPPP 361
                .|..|..|.:|...|:..|::   :||        .||...|.|..|.| ||.....||..
Human   204 ----QPTPGAHLPHPFPLPAAHAAL---HNP--------RPGPLLGAPAPPQPVPGAYPNTGPGR 253

  Fly   362 PPFVAPPTSSELYQRLQYQQLLHQHAAAAALAAHQRQLSVAAASAASQPPPTHHHPHLAVGQAPL 426
            .|:.                |||.|.        .|.|.::|.:.|..|..
Human   254 RPYA----------------LLHPHP--------PRYLLLSAPAYAGAPKK-------------- 280

  Fly   427 SPGGDSPGPSPQPLHKPVTVVS 448
            :.|.|...|:|.|...|..|:|
Human   281 AEGADLATPAPFPCCSPHLVLS 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	FH_FOXG	180..258	CDD:410795	51/77 (66%)
FOXD4	NP_997188.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		13/48 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..104		11/76 (14%)
		FH_FOXD4-like	104..199	CDD:410822	58/94 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..232		10/38 (26%)