DRSC/TRiP Functional Genomics Resources

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Protein Alignment slp2 and FOXG1

DIOPT Version :9

Sequence 1:NP_476834.1 Gene:slp2 / 33608 FlyBaseID:FBgn0004567 Length:451 Species:Drosophila melanogaster
Sequence 2:NP_005240.3 Gene:FOXG1 / 2290 HGNCID:3811 Length:489 Species:Homo sapiens


Alignment Length:499 Identity:179/499 - (35%)
Similarity:210/499 - (42%) Gaps:176/499 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 HSLHFQHHHHPLPPTTHHSALQSPHPVGLNLTNLMKMARTPHLKSSFSINSILPETVEHHDEDEE 80
            |..|..|||||.||     |.|.|.|                           |:        ::
Human    48 HHHHHHHHHHPPPP-----APQPPPP---------------------------PQ--------QQ 72

  Fly    81 EDVEKKSPAKFPPNHNNNNLNTTNWGSPEDHEAESD--PESDLDVTSMSPAPVA----------- 132
            :......||..||...         |:|   .|:.|  |:..|......|.|.|           
Human    73 QPPPPPPPAPQPPQTR---------GAP---AADDDKGPQQLLLPPPPPPPPAAALDGAKADGLG 125

  Fly   133 -------NPNESDPDEVDEEFVEEDIECDGETTDGDAE-NKSNDGKPVKDKKGN--EKPPYSYNA 187
                   .|.|..|...||:  |:.....||...|..| .|..:|....:||..  ||||:||||
Human   126 GKGEPGGGPGELAPVGPDEK--EKGAGAGGEEKKGAGEGGKDGEGGKEGEKKNGKYEKPPFSYNA 188

  Fly   188 LIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGN 252
            |||||||||.|||||||||||:||.|.||||:|||||||||||||||||||||||||||||||||
Human   189 LIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGN 253

  Fly   253 YWMLDPSAEDVFIGGSTGKLRRRTTAASRSRLAAFKR----------------SLIGPMFPGLAA 301
            |||||||::||||||:|||||||:| .||::| ||||                ||..||.|.|:.
Human   254 YWMLDPSSDDVFIGGTTGKLRRRST-TSRAKL-AFKRGARLTSTGLTFMDRAGSLYWPMSPFLSL 316

  Fly   302 -YPQFGQFLTYPPTAPSLLASMYQRYNPFAPKGGPGHPGLPPGLPGLPGPPGPQGPPGPPPPPFV 365
             :|:....|:|..|     .|.|           |.||                           
Human   317 HHPRASSTLSYNGT-----TSAY-----------PSHP--------------------------- 338

  Fly   366 APPTSSELYQR-------------LQYQQLLH-------QHAAAAALAAH-QRQLSVAAASAASQ 409
             .|.||.|.|.             |...:|::       .|..||||||. ...|||..:...|.
Human   339 -MPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSL 402

  Fly   410 PP--------------PTHHHPHL-AVGQAPLSPGGDSPGPSPQ 438
            .|              |...||.: :.....:|....|...|||
Human   403 NPCSVNLLAGQTSYFFPHVPHPSMTSQSSTSMSARAASSSTSPQ 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slp2NP_476834.1 Forkhead 180..265 CDD:306709 76/84 (90%)
FOXG1NP_005240.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..181 41/186 (22%)
FH_FOXG 181..259 CDD:410795 71/77 (92%)
COG5025 <184..>356 CDD:227358 112/217 (52%)
Required for interaction with TLE6. /evidence=ECO:0000250|UniProtKB:Q60987 249..344 50/140 (36%)
Interaction with KDM5B. /evidence=ECO:0000269|PubMed:12657635 383..406 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 427..455 5/20 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 172 1.000 Domainoid score I3743
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 214 1.000 Inparanoid score I3629
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 1 1.000 - - otm42140
orthoMCL 1 0.900 - - OOG6_107705
Panther 1 1.100 - - LDO PTHR46617
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2114
SonicParanoid 1 1.000 - - X1751
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.900

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