DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp2 and FOXD4L1

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_036316.1	Gene:	FOXD4L1 / 200350	HGNCID:	18521	Length:	408	Species:	Homo sapiens

Alignment Length:	402	Identity:	127/402 - (31%)
Similarity:	158/402 - (39%)	Gaps:	104/402 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LNLTNLMKMARTPH--LKSSFSINSILPETVEHHDEDEEEDVEKKSPAKFPPNHNNNNLNTTNWG 106
            :||....:...||.  |:.|...:..:....|..||||.||.|:::..||........|....||
Human     1 MNLPRAERPRSTPQRSLRDSDGEDGKIDVLGEEEDEDEVEDEEEEASQKFLEQSLQPGLQVARWG 65

  Fly   107 S---PEDHEAESDPESDLDVTSMSPAPVANPNESDPDEVDEEFVEEDIECDGETTDGDAENKSND 168
            .   |.:|.....|                   |||.|...||                ......
Human    66 GVALPREHIEGGGP-------------------SDPSEFGTEF----------------RAPPRS 95

  Fly   169 GKPVKDKKGNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLS 233
            ....:|.:...||||||.|||.|||.||..|||||:||..:|....||||.....||||||||||
Human    96 AAASEDARQPAKPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLS 160

  Fly   234 LNKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRLAAFKRSLIGPMFPG 298
            ||.||||:||....||||.||.|||:::|:|..||..:.|:|           |||..:.|
Human   161 LNDCFVKIPREPGHPGKGTYWSLDPASQDMFDNGSFLRRRKR-----------FKRHQLTP---- 210

  Fly   299 LAAYPQFGQFLTYPPTAPSLLASMYQRYNPFAPKGGP--GHPGLPPGLPGLPGPPGPQGPPGPPP 361
                   |..|.:|...|:..|:::.      |:.||  |.|.||..:||    ..|...||..|
Human   211 -------GAHLPHPFPLPAAHAALHN------PRPGPLLGAPALPQPVPG----AYPNTAPGRRP 258

  Fly   362 PPFVAPPTSSELYQRLQYQQLLHQHAAAAALAAHQRQLSVAAASAASQPPPTHHHPHLAVGQAP- 425
                              ..|||.|.        .|.|.::|.:.|..|...........|..|
Human   259 ------------------YALLHPHP--------PRYLLLSAPAYAGAPKKAEGADLATPGTLPV 297

  Fly   426 LSPGGDSPGPSP 437
            |.|   |.||.|
Human   298 LQP---SLGPQP 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	54/84 (64%)
FOXD4L1	NP_036316.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		16/52 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..104		9/67 (13%)
		Forkhead	107..193	CDD:278670	55/85 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..408
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820