DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slp2 and Foxa2

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001277994.1	Gene:	Foxa2 / 15376	MGIID:	1347476	Length:	465	Species:	Mus musculus

Alignment Length:	376	Identity:	116/376 - (30%)
Similarity:	148/376 - (39%)	Gaps:	109/376 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 SMSP------------APVANPNESDPDEVDEEFVEEDIECDGETTDGDAE-NKSNDGKPVKDKK 176
            |:||            ||.||.|...|                  ..|.|. :::.|.|..:...
Mouse   115 SLSPLGGQAAGAMGGLAPYANMNSMSP------------------MYGQAGLSRARDPKTYRRSY 161

  Fly   177 GNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSLNKCFVKV 241
            .:.||||||.:||.|||:||..|.|||:.||::||...|:||.|:|.|||||||:||.|.||:||
Mouse   162 THAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKV 226

  Fly   242 PRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRLAAFKRSLIGPMFPG-------- 298
            ||..|.||||::|.|.|.:.::|..|.  .|||:.......:||.  :...|....|
Mouse   227 PRSPDKPGKGSFWTLHPDSGNMFENGC--YLRRQKRFKCEKQLAL--KEAAGAASSGGKKTAPGS 287

  Fly   299 LAAYPQFGQFLTYPPTAPSLLASMYQRYNPFAP---------KGGPGHPGLPPGLPGLPGP-PGP 353
            .|:..|.|:........|:...|.:...:|...         ||.|.....||.    |.| ||.
Mouse   288 QASQAQLGEAAGSASETPAGTESPHSSASPCQEHKRGGLSELKGAPASALSPPE----PAPSPGQ 348

  Fly   354 Q--------GP---PGPPPPPFVAP--------PTSSELYQRLQYQQLLHQHAAAAALAAHQRQL 399
            |        ||   ||.||...:.|        |.|   ...|...:..|.|       :|.
Mouse   349 QQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFS---INNLMSSEQQHHH-------SHH--- 400

  Fly   400 SVAAASAASQPPPTHHHPH----LAVGQAPLSPGG-DSPGPSPQPLHKPVT 445
                          ||.||    .|..|....||| .||.|....: .|||
Mouse   401 --------------HHQPHKMDLKAYEQVMHYPGGYGSPMPGSLAM-GPVT 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	50/84 (60%)
Foxa2	NP_001277994.1	Forkhead_N	23..164	CDD:254796	13/66 (20%)
		FH	165..253	CDD:214627	51/87 (59%)
		DUF4799	<224..319	CDD:292674	27/98 (28%)
		HNF_C	381..454	CDD:286443	21/84 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910