DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp2 and Foxg1

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001153584.1	Gene:	Foxg1 / 15228	MGIID:	1347464	Length:	481	Species:	Mus musculus

Alignment Length:	474	Identity:	177/474 - (37%)
Similarity:	210/474 - (44%)	Gaps:	144/474 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KSSFSINSILPETVE------------------HHDEDEEEDVEKKSPAKFPPNHNNNNLNTTNW 105
            ||||||||::||.|:                  ||...........:|...||..........
Mouse    15 KSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHPPPPAPQPPPPPPQQQQQQPP-- 77

  Fly   106 GSPEDHEAESDPESDLD----------VTSMSPA----------PVANPNESDPDEVDEEFVEED 150
            .:|:..:|...|.:|.|          .|::..|          |...|.|..|...||:  |:.
Mouse    78 PAPQPPQARGAPAADDDKGPQPLLLPPSTALDGAKADALGAKGEPGGGPAELAPVGPDEK--EKG 140

  Fly   151 IECDGETTDGDAE-NKSNDGKPVKDKKGN--EKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMT 212
            ....||...|..| .|..:|....|||..  ||||:|||||||||||||.|||||||||||:||.
Mouse   141 AGAGGEEKKGAGEGGKDGEGGKEGDKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMK 205

  Fly   213 NHPYYRDNKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTT 277
            |.||||:||||||||||||||||||||||||||||||||||||||||::||||||:|||||||:|
Mouse   206 NFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRST 270

  Fly   278 AASRSRLAAFKR----------------SLIGPMFPGLAA-YPQFGQFLTYPPTAPSLLASMYQR 325
             .||::| ||||                ||..||.|.|:. :|:....|:|..|     .|.|
Mouse   271 -TSRAKL-AFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGT-----TSAY-- 326

  Fly   326 YNPFAPKGGPGHPGLPPGLPGLPGPPGPQGPPGPPPPPFVAPPTSSELYQR-------------L 377
                     |.||                            .|.||.|.|.             |
Mouse   327 ---------PSHP----------------------------MPYSSVLTQNSLGNNHSFSTANGL 354

  Fly   378 QYQQLLH-------QHAAAAALAAH-QRQLSVAAASAASQPP--------------PTHHHPHL- 419
            ...:|::       .|..||||||. ...|||..:...|..|              |...||.:
Mouse   355 SVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMT 419

  Fly   420 AVGQAPLSPGGDSPGPSPQ 438
            :.....:|....|...|||
Mouse   420 SQTSTSMSARAASSSTSPQ 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	76/84 (90%)
Foxg1	NP_001153584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..173		28/145 (19%)
		FH	173..261	CDD:214627	79/87 (91%)
		Required for interaction with TLE6. /evidence=ECO:0000269\|PubMed:16314515	241..336		50/140 (36%)
		Interaction with KDM5B. /evidence=ECO:0000250	375..398		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..447		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3724
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm44194
orthoMCL	1	0.900	-	-		OOG6_107705
Panther	1	1.100	-	-	LDO	PTHR46617
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	1	1.000	-	-		X1751
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860