DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and Foxk2

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	XP_011247520.1	Gene:	Foxk2 / 68837	MGIID:	1916087	Length:	690	Species:	Mus musculus

Alignment Length:	329	Identity:	90/329 - (27%)
Similarity:	135/329 - (41%)	Gaps:	79/329 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KPINTATQPIKTEPVHHHHQYVHPYSNSDGELSASEDFDSPSRTSTPMSSAAESLSSQNNDKLDV 85
            ||:.....|:...........:.|..:..|.:||:....|..|.:   .|:...:.......|.:
Mouse   203 KPVQPHISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGA---GSSGYKVGRVMPSDLSL 264

  Fly    86 EFDDELEDQLDEDQESEDGNPSKKQKMTAGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYL 150
            ..|:   .|.:.::|:..|:..|        |..||||||..||:.||..:|:::|||||||.::
Mouse   265 MADN---SQPENEKEASGGDSPK--------DDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHI 318

  Fly   151 INRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRK 215
            ...:||::...:|||||||||||||:.|.|:|||.::||||::|.:||::|...:.:...|.|.:
Mouse   319 TKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLVEQAFRKRRPR 383

  Fly   216 ---------------------------------------------------NPGASRTRLAAYRQ 229
                                                               .||||:.:||..::
Mouse   384 GVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGASQPKLAVIQE 448

  Fly   230 AIFSPMMAASPYGAPASSYGYPAVPFAAAAAAALYQRMNPAAYQAAYQQMQYQQAP---QAHH-- 289
            |.|    |.|..|:|.||.     |........|...:.|..|..|.........|   |..|
Mouse   449 ARF----AQSAPGSPLSSQ-----PVLITVQRQLPPAIKPVTYTVATPVTTPTSQPPVVQTVHVV 504

  Fly   290 HQAP 293
            ||.|
Mouse   505 HQIP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	46/84 (55%)
Foxk2	XP_011247520.1	FHA	41..>124	CDD:238017
		COG5025	<175..>381	CDD:227358	64/191 (34%)
		Forkhead	287..373	CDD:365978	46/85 (54%)
		PHA03247	<380..683	CDD:223021	26/138 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850