DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and FOXB2

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_001013757.1	Gene:	FOXB2 / 442425	HGNCID:	23315	Length:	432	Species:	Homo sapiens

Alignment Length:	179	Identity:	68/179 - (37%)
Similarity:	93/179 - (51%)	Gaps:	26/179 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 KKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPR 183
            :||||||.:|..||||.|.|:.|.|:.||::::.||||::.:.:.||||:|||||.|.||.||||
Human    12 QKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQRWQNSLRHNLSFNDCFIKIPR 76

  Fly   184 SYDDPGKGNYWILDPSAEEVFIGETTGKLRRKNPGASRTRLAAYRQAIFSPMMAASPYGAPASSY 248
            ..|.||||::|.|.|...::|  |....|||      |.|....| |..:.:.|.|...||.:..
Human    77 RPDQPGKGSFWALHPDCGDMF--ENGSFLRR------RKRFKVLR-ADHTHLHAGSTKSAPGAGP 132

  Fly   249 GYPAVPFAAAAAAALYQRMNPAAYQAAYQQMQYQQAPQAHHHQAPHPAQ 297
            |               ..::|..:...:....:..|  ||||...||.|
Human   133 G---------------GHLHPHHHHHPHHHHHHHAA--AHHHHHHHPPQ 164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	45/84 (54%)
FOXB2	NP_001013757.1	FH	13..101	CDD:214627	47/89 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..220		14/64 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940