DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and FOXK2

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_004505.2	Gene:	FOXK2 / 3607	HGNCID:	6036	Length:	660	Species:	Homo sapiens

Alignment Length:	349	Identity:	98/349 - (28%)
Similarity:	146/349 - (41%)	Gaps:	84/349 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VKSEMEFKSNFSIDAILAKKP-INTATQPIKTEPVHHHHQYVHPYSNSDGELSASEDFDSPSRTS 65
            :.||...|...|...:.|.:| |:..|..|.....|    .:.|..:..|.:||:....|..|.:
Human   157 LSSEKREKQEASESPVKAVQPHISPLTINIPDTMAH----LISPLPSPTGTISAANSCPSSPRGA 217

  Fly    66 TPMSSAAESLSSQNNDKLDVEFDDELEDQLDEDQESEDGNPSKKQKMTAGSDTKKPPYSYNALIM 130
               .|:...:.......|::..|:   .|.:.::|:..|:..|        |..||||||..||:
Human   218 ---GSSGYKVGRVMPSDLNLMADN---SQPENEKEASGGDSPK--------DDSKPPYSYAQLIV 268

  Fly   131 MAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWI 195
            .||..:|:::|||||||.::...:||::...:|||||||||||||:.|.|:|||.::||||::|.
Human   269 QAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWR 333

  Fly   196 LDPSAEEVFIGETTGKLRRK--------------------------------------------- 215
            :||::|...|.:...|.|.:
Human   334 IDPASESKLIEQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGS 398

  Fly   216 ------NPGASRTRLAAYRQAIFSPMMAASPYGAPASSYGYPAVPFAAAAAAALYQRMNPAAYQA 274
                  .|||::.:||..::|.|    |.|..|:|.||.     |........|.|.:.|..|..
Human   399 PAPLEPEPGAAQPKLAVIQEARF----AQSAPGSPLSSQ-----PVLITVQRQLPQAIKPVTYTV 454

  Fly   275 AYQQMQYQQAP---QAHH--HQAP 293
            |.........|   |..|  ||.|
Human   455 ATPVTTSTSQPPVVQTVHVVHQIP 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	46/84 (55%)
FOXK2	NP_004505.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		FHA	47..154	CDD:238017
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..104
		Required for interaction with DVL2 and SUDS3. /evidence=ECO:0000269\|PubMed:25805136	129..171		4/13 (31%)
		COG5025	<180..577	CDD:227358	91/326 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..260		13/70 (19%)
		Forkhead	257..343	CDD:365978	46/85 (54%)
		DNA-binding, major groove. /evidence=ECO:0000269\|PubMed:16624804	300..318		14/17 (82%)
		DNA-binding, minor groove. /evidence=ECO:0000269\|PubMed:16624804	328..332		2/3 (67%)
		DNA-binding, minor groove. /evidence=ECO:0000269\|PubMed:16624804	348..353		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..407		0/47 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..632
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1826
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800