DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and FOXI3

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_001129121.1	Gene:	FOXI3 / 344167	HGNCID:	35123	Length:	420	Species:	Homo sapiens

Alignment Length:	248	Identity:	81/248 - (32%)
Similarity:	121/248 - (48%)	Gaps:	48/248 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 KPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRS 184
            :|||||:|||.||||.:||::|||:.|||::.:.||:::.:|.|||||||||||||.||.|:||.
Human   145 RPPYSYSALIAMAIQSAPERKLTLSHIYQFVADSFPFYQRSKAGWQNSIRHNLSLNDCFKKVPRD 209

  Fly   185 YDDPGKGNYWILDPSAEEVF-IGETTGKLRRKNPGASRTRLAA------------------YRQA 230
            .|||||||||.|||:.|::| .|....|.:|::..::.:.:||                  .:..
Human   210 EDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRRSEASNGSTVAAGTSKSEEGLSSGLGSGVGGKPE 274

  Fly   231 IFSPMMAASPYGAP---------ASSYGYP-------------AVPFAAAAAAALYQRMNPAAYQ 273
            ..||.....|..:|         |||.|.|             ::...:.:::...||..|.:..
Human   275 EESPSTLLRPSHSPEPPEGTKSTASSPGGPMLTSTPCLNTFFSSLSSLSVSSSVSTQRALPGSRH 339

  Fly   274 AAYQQMQYQQ----APQAHHHQAPHPAQMQGYPQQLNAELFQRMQFFGKFPSS 322
            ...|..|...    :|.:....:....|:.........   ||..::..||:|
Human   340 LGIQGAQLPSSGVFSPTSISEASADTLQLSNSTSNSTG---QRSSYYSPFPAS 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	55/85 (65%)
FOXI3	NP_001129121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..122
		Forkhead	145..231	CDD:278670	55/85 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..306		13/71 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396		6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820