DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and foxk1

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_956196.1	Gene:	foxk1 / 334470	ZFINID:	ZDB-GENE-030131-6402	Length:	639	Species:	Danio rerio

Alignment Length:	323	Identity:	89/323 - (27%)
Similarity:	148/323 - (45%)	Gaps:	55/323 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KPINTATQPIK-TEPVHHHHQYVHPYSNSDGELSASEDFDSPSRTSTPMSSAAESLSSQNNDKLD 84
            :|:.....|:| |.|.:.....:.|..:..|.:|...     |..::|..:.:.......|...|
Zfish   169 RPLYPQISPLKITIPDNDFKTMMSPLPSPTGTISVPN-----SCPASPRGAGSSGYRYGRNITSD 228

  Fly    85 VEFDDELEDQLDEDQESE-DGNPSKKQKMTAGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQ 148
            ::...|...:...:|.:| .|..|.|       |..||||||..||:.||..:.:::|||:|||.
Zfish   229 LQLAAEYAAKAVSEQRTEATGGDSPK-------DESKPPYSYAQLIVQAISSAQDRQLTLSGIYA 286

  Fly   149 YLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLR 213
            ::...:||::...:|||||||||||||:.|.|:|||.::||||::|.:|||:|...:.:...|.|
Zfish   287 HITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRVDPSSEAKLVEQAFRKRR 351

  Fly   214 RKNPGASRTRLAAYRQAIFSPMMAASPYGAPASSYGYPAVPFAAAAAA----------ALYQRMN 268
            ::.....||                 |:| |.||...||.|..:...:          .|.:..:
Zfish   352 QRGVSCFRT-----------------PFG-PLSSRSAPASPTHSGLLSPHSSGLQTPECLSREGS 398

  Fly   269 PAAYQ-------AAYQQMQYQQAPQAHHHQAPHPAQ--MQGYPQQLNAELFQRMQFFGKFPSS 322
            |.:::       |:..:.:|.|:...    :|..||  :...|.|.:|.:.:.:.:.....||
Zfish   399 PVSHEHDFGSKLASVPEYRYSQSAPG----SPVSAQPVIMAVPSQSSAAISKPVAYMPSIISS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	45/84 (54%)
foxk1	NP_956196.1	FHA	23..165	CDD:224630
		FHA	68..152	CDD:238017
		Forkhead	258..344	CDD:278670	45/85 (53%)
		Cyto_heme_lyase	370..>465	CDD:279589	16/92 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850