DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and foxk2a

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_001184186.1	Gene:	foxk2a / 324141	ZFINID:	ZDB-GENE-030131-2861	Length:	544	Species:	Danio rerio

Alignment Length:	336	Identity:	102/336 - (30%)
Similarity:	146/336 - (43%)	Gaps:	72/336 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PINTATQPIK---TEPVHHHHQYVHPYSNSDGELSASEDFDSPSRTSTPMSSAAESLSSQNNDK- 82
            |:.....|:.   .|.:.|...   |..:..|.:||:        .|.|.|.....|||....:
Zfish   122 PVKAQISPLTISIPENITHLRS---PLPSPTGTISAA--------NSCPSSPRGAGLSSYRMGRG 175

  Fly    83 LDVEFDDELEDQLDEDQESEDGNPSKKQKMTAGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIY 147
            |..|..:| ..|.:.|:|:..|:..|        |..||||||..||:.||..:|:::|||||||
Zfish   176 LTAELINE-NSQSEIDKEASGGDSPK--------DDSKPPYSYAQLIVQAITMAPDKQLTLNGIY 231

  Fly   148 QYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKL 212
            .::...:||::...:|||||||||||||:.|.|:.||.::||||::|.:|||:|...:.:...|.
Zfish   232 THITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVARSQEEPGKGSFWRIDPSSEGKLMDQAFRKR 296

  Fly   213 RRKNPGASRTRLA--AYRQAIFSP----MMAASPYG--APASS---YGYPAVPFAAAAAA----- 261
            |.:.....||.|.  :.|.|..||    :::|...|  .|.||   ...|..|..:||||
Zfish   297 RPRGVPCFRTPLGPLSSRSAPASPTHTGVLSAHSSGVQTPDSSREGSPLPLEPEPSAAAAPQPKL 361

  Fly   262 -----------------------ALYQRMNPAAYQAAYQQMQYQQAP--QAHH--HQAP-----H 294
                                   .|.|.:.|.::..|.........|  |..|  ||.|     .
Zfish   362 AVIQESCFTQNTPGSPVLIAVQQPLQQSLKPVSFSVATPASSAAPQPVMQTLHLLHQIPAACVFR 426

  Fly   295 PAQMQGYPQQL 305
            ..|..|..|::
Zfish   427 AEQQNGDAQEV 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	46/84 (55%)
foxk2a	NP_001184186.1	FHA	16..105	CDD:238017
foxk2a	NP_001184186.1	Forkhead	204..290	CDD:278670	46/85 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850