DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and fhl1

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_594272.1	Gene:	fhl1 / 2541552	PomBaseID:	SPAC1142.08	Length:	743	Species:	Schizosaccharomyces pombe

Alignment Length:	410	Identity:	98/410 - (23%)
Similarity:	155/410 - (37%)	Gaps:	133/410 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEMEFKSNFSIDAILAKKPINTATQPIKTEPVHHHHQYVHPYSNSDGELSASEDFDSPSRTSTPM 68
            |.::.:|:..:....|...|:.||..|:           ||.:.:...|::   .:.|.:..|..
pombe   172 SHIKHESDLPLGLSPADTNISNATSIIE-----------HPDAANAHTLAS---LNQPPKHLTVS 222

  Fly    69 SSAAESLSSQ-----NNDKLDVEFDDELE--DQLDEDQESEDG----------NPSKKQKMTAGS 116
            .|:.:.||.|     .:|:..:|.|..:.  ...:.|:|.:.|          :|........|.
pombe   223 PSSIQRLSPQPYVRPTSDERPIETDSSVSAPKVANHDEELKQGKSTSPSDTVLHPDLNGSPDTGD 287

  Fly   117 DTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKI 181
            .|:||..||..||...:..:|.:::||..|.:::.|.:.|::.....|.|||||||||||.|.:|
pombe   288 ATQKPNLSYANLIARTLIANPNKKMTLGDICEWIANNWSYYRHQPPAWHNSIRHNLSLNKAFIRI 352

  Fly   182 PRSYDDPGKGNYWILDPSAEEVFIGE----------------------------------TTGKL 212
            ||..::||||::|:||||..:.|.|.                                  :.||.
pombe   353 PRRQNEPGKGSFWMLDPSYIDQFEGNFFRRTKKPTPSATPAAHPDTARENELAAIQTKGISAGKT 417

  Fly   213 RRKNP--GASRTRLAAYR------------QAIFSPM------MAASP---------YGAPASSY 248
            .:.||  ..||::....|            |....|:      :|.:|         ..||...
pombe   418 EQLNPQKETSRSKTHTSRGENVEDRPQSLLQNGIQPIIMRDGKLALNPEFFKNANGEQQAPNEQ- 481

  Fly   249 GYPAVPFAAAAAAALYQRMN----PAAYQ--------------AAYQQMQYQQAPQAHHHQAPHP 295
                   |..|.:.|.|.:|    |||..              |..|::|.||
pombe   482 -------AVQAISLLQQHINKQLGPAAANNPEQATAIANALAVALAQKLQKQQ------------ 527

  Fly   296 AQMQGYPQQLNAELFQRMQF 315
            .|||| |||:..:..:|..:
pombe   528 TQMQG-PQQVQQQAKRRKAY 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	37/84 (44%)
fhl1	NP_594272.1	COG5025	1..564	CDD:227358	98/410 (24%)
		FHA	<38..119	CDD:238017
		Forkhead	291..376	CDD:278670	37/84 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm47190
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840