DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and FOXM1

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_973731.1	Gene:	FOXM1 / 2305	HGNCID:	3818	Length:	801	Species:	Homo sapiens

Alignment Length:	245	Identity:	71/245 - (28%)
Similarity:	111/245 - (45%)	Gaps:	36/245 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SDGELSASEDFDSPSRTSTPMSSAAESLSSQNNDKLDVEFDDELEDQLDEDQESEDGNPSKKQKM 112
            :|||.:.....:|.|........:::.|.|::   :..|.:::....|::.|...: .||:....
Human   168 ADGEAAGCTINNSLSNIQWLRKMSSDGLGSRS---IKQEMEEKENCHLEQRQVKVE-EPSRPSAS 228

  Fly   113 TAGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFK-ANKRGWQNSIRHNLSLNK 176
            ...|.:::|||||.|:|..||..:..:|:||..||.::.:.||||| ..|.||:|||||||||:.
Human   229 WQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHD 293

  Fly   177 CFTKIPRSYDDPGKGNYWILDPSA------EEVFIGETTG----------KLRRKNPGASR---- 221
            .|.   |.....||.::|.:.|||      ::||.....|          :.:|.||...|
Human   294 MFV---RETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTI 355

  Fly   222 -TRLAAYRQAIFSPMM-AASPYGAP------ASSYGYPAVPFAAAAAAAL 263
             |.|....:....|:: ..|.|..|      .|....|:|......||:|
Human   356 KTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	40/91 (44%)
FOXM1	NP_973731.1	FH	236..311	CDD:238016	36/77 (47%)
FOXM1	NP_973731.1	Herpes_ICP4_C	504..>749	CDD:332854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820