DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and FOXC2

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_005242.1	Gene:	FOXC2 / 2303	HGNCID:	3801	Length:	501	Species:	Homo sapiens

Alignment Length:	221	Identity:	87/221 - (39%)
Similarity:	119/221 - (53%)	Gaps:	45/221 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 PSKKQKMTAGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRH 170
            |....:..|..|..||||||.|||.||||::||:::|||||||::::|||:::.||:||||||||
Human    58 PYHHHQPAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRH 122

  Fly   171 NLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRR----KNPGASRTRLAAYRQAI 231
            |||||:||.|:||....||||:||.|||.:..:|  |....|||    |....|:.:  ..|..:
Human   123 NLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMF--ENGSFLRRRRRFKKKDVSKEK--EERAHL 183

  Fly   232 FSPMMAASPYGAPASSYGYPAVPFAA---------------AAAAAL-----YQRMNP-AAYQAA 275
            ..|        .||:|.|.||.|..|               ||:.||     .:.::| :|.|.:
Human   184 KEP--------PPAASKGAPATPHLADAPKEAEKKVVIKSEAASPALPVITKVETLSPESALQGS 240

  Fly   276 YQQMQYQQA-------PQAHHHQAPH 294
            .:......|       |: ||..||:
Human   241 PRSAASTPAGSPDGSLPE-HHAAAPN 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	54/84 (64%)
FOXC2	NP_005242.1	FH	72..160	CDD:214627	56/89 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..208		12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..268		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920