DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and FOXD1

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_004463.1	Gene:	FOXD1 / 2297	HGNCID:	3802	Length:	465	Species:	Homo sapiens

Alignment Length:	289	Identity:	100/289 - (34%)
Similarity:	129/289 - (44%)	Gaps:	89/289 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DDELEDQLDEDQESED--------GNPSKKQKM--------------------TAGSDTK----K 120
            :||||| |:|:::.:|        |:|:.....                    :|||..|    |
Human    62 EDELED-LEEEEDDDDILLAPPAGGSPAPPGPAPAAGAGAGGGGGGGGAGGGGSAGSGAKNPLVK 125

  Fly   121 PPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSY 185
            |||||.|||.|||..||::||||:.|.:::..||||::.....||||||||||||.||.||||..
Human   126 PPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREP 190

  Fly   186 DDPGKGNYWILDPSAEEVFIGETTGKLRRK-----------NPGASRTRL------------AAY 227
            .:|||||||.|||.:.::|  :....|||:           |..|:.:.|            .|.
Human   191 GNPGKGNYWTLDPESADMF--DNGSFLRRRKRFKRQPLLPPNAAAAESLLLRGAGAAGGAGDPAA 253

  Fly   228 RQAIFSPMMAASP-----------YGAPASSYGYPAVPFAAAAAAALYQRMNPAAYQAAYQQMQY 281
            ..|:|.|.....|           ||.....|..|:..||||||||       ||  ||:
Human   254 AAALFPPAPPPPPHAYGYGPYGCGYGLQLPPYAPPSALFAAAAAAA-------AA--AAF----- 304

  Fly   282 QQAPQAHHHQAPHPAQMQGYPQQLNAELF 310
                  |.|..|.|....|...:|....|
Human   305 ------HPHSPPPPPPPHGAAAELARTAF 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	51/84 (61%)
FOXD1	NP_004463.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117		11/55 (20%)
		Forkhead	125..211	CDD:278670	52/87 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920