DRSC/TRiP Functional Genomics Resources

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Protein Alignment slp1 and FOXC1

DIOPT Version :9

Sequence 1:NP_476730.1 Gene:slp1 / 33607 FlyBaseID:FBgn0003430 Length:322 Species:Drosophila melanogaster
Sequence 2:NP_001444.2 Gene:FOXC1 / 2296 HGNCID:3800 Length:553 Species:Homo sapiens


Alignment Length:256 Identity:84/256 - (32%)
Similarity:119/256 - (46%) Gaps:65/256 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 DTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKI 181
            |..||||||.|||.||||::|::::|||||||::::|||:::.||:|||||||||||||:||.|:
Human    75 DMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKV 139

  Fly   182 PRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRKN-----------------------PGASRTR 223
            ||....||||:||.|||.:..:|  |....|||:.                       |...:..
Human   140 PRDDKKPGKGSYWTLDPDSYNMF--ENGSFLRRRRRFKKKDAVKDKEEKDRLHLKEPPPPGRQPP 202

  Fly   224 LAAYRQA-----------------------IFSPMMAASPYGA--PASSYGYPAVPFAAAAAAAL 263
            .|...||                       ..||....||..|  ..|:...|.:....:::::|
Human   203 PAPPEQADGNAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAAAVPKIESPDSSSSSL 267

  Fly   264 YQRMNPAAYQAAYQQMQYQQA-----PQAHHHQAPHPAQ----------MQGYPQQLNAEL 309
            ....:|.....:.:.:....|     |.|.....||.:|          ::|.||...|||
Human   268 SSGSSPPGSLPSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAAEL 328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slp1NP_476730.1 FH 120..205 CDD:214627 53/84 (63%)
FOXC1NP_001444.2 Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 1..51
FH 78..166 CDD:214627 55/89 (62%)
Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269|PubMed:11782474 78..93 12/14 (86%)
Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269|PubMed:11782474 168..176 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..310 19/136 (14%)
Required for transcriptional inhibition. /evidence=ECO:0000269|PubMed:11782474 215..366 21/114 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..387
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..465
Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 466..553
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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