DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and FOXF2

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_001443.1	Gene:	FOXF2 / 2295	HGNCID:	3810	Length:	444	Species:	Homo sapiens

Alignment Length:	306	Identity:	96/306 - (31%)
Similarity:	136/306 - (44%)	Gaps:	63/306 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AKKPINTATQPIKTEPVHHHHQYVHPYSNSDGELSASEDFDSPSRTSTPMSSAAESLSSQNNDKL 83
            |..|:..|.|.....|         |.:.:....:|.|...|.|.:|:  :|.|.|.||.|:...
Human    15 ACSPVPGALQAALMSP---------PPAAAAAAAAAPETTSSSSSSSS--ASCASSSSSSNSASA 68

  Fly    84 DVEFDDELEDQLDEDQESEDGNPSKKQKMTAGSDT-----------------KKPPYSYNALIMM 131
                                  ||...|...|...                 :||||||.|||:|
Human    69 ----------------------PSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVM 111

  Fly   132 AIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWIL 196
            |||.||.:||||:.|||:|..|||:|:...:||:||:|||||||:||.|:|:....||||:||.:
Human   112 AIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTI 176

  Fly   197 DPSAEEVFIGETTGKLRRKNPGASRTRLAAYRQAIFSPMMAASPYGAPASSYGY-----PAVPFA 256
            ||::|.:|   ..|..||: |...|.:..|.: .::..:::...:||.....|:     |:.|..
Human   177 DPASEFMF---EEGSFRRR-PRGFRRKCQALK-PMYHRVVSGLGFGASLLPQGFDFQAPPSAPLG 236

  Fly   257 AAAAAALY--QRMNPAAYQAAYQQMQYQQAPQAHHHQAPHPAQMQG 300
            ..:... |  ..|.||.|.|......:......|||..||.:...|
Human   237 CHSQGG-YGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPG 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	51/84 (61%)
FOXF2	NP_001443.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..98		15/89 (17%)
		FH	100..188	CDD:214627	52/90 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..323		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910