DRSC/TRiP Functional Genomics Resources

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Protein Alignment slp1 and FOXG1

DIOPT Version :9

Sequence 1:NP_476730.1 Gene:slp1 / 33607 FlyBaseID:FBgn0003430 Length:322 Species:Drosophila melanogaster
Sequence 2:NP_005240.3 Gene:FOXG1 / 2290 HGNCID:3811 Length:489 Species:Homo sapiens


Alignment Length:366 Identity:120/366 - (32%)
Similarity:172/366 - (46%) Gaps:86/366 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KSNFSIDAILAKKPIN-----TATQPIKTEPVHHHHQYVH------------------------- 43
            ||:|||::::.:...|     :........|.||||.:.|                         
Human    15 KSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHHPPPPAPQPPPPPQQQQPPPPPP 79

  Fly    44 --PYSNSDGELSASEDFDSPSR---TSTPMSSAAESLSSQNNDKLDVEFD-------------DE 90
              |.........|::|...|.:   ...|....|.:|.....|.|..:.:             ||
Human    80 PAPQPPQTRGAPAADDDKGPQQLLLPPPPPPPPAAALDGAKADGLGGKGEPGGGPGELAPVGPDE 144

  Fly    91 L--------EDQLDEDQESEDGNPSKKQKMTAGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIY 147
            .        |::....:..:||...|:.:...|. .:|||:||||||||||:.|||:||||||||
Human   145 KEKGAGAGGEEKKGAGEGGKDGEGGKEGEKKNGK-YEKPPFSYNALIMMAIRQSPEKRLTLNGIY 208

  Fly   148 QYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKL 212
            ::::..|||::.||:||||||||||||||||.|:||.||||||||||:||||:::||||.|||||
Human   209 EFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKL 273

  Fly   213 RRKNPGASRTRLAAYRQA---------------IFSPM---------MAASPYGAPASSYGYPAV 253
            ||::. .||.:||..|.|               ::.||         .|:|......::..||:.
Human   274 RRRST-TSRAKLAFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSH 337

  Fly   254 PFAAAAAAALYQRMNPAAYQAA----YQQMQYQQAPQAHHH 290
            |...::........|..::..|    ..::...:.|.|.||
Human   338 PMPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHH 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slp1NP_476730.1 FH 120..205 CDD:214627 63/84 (75%)
FOXG1NP_005240.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..181 22/150 (15%)
FH_FOXG 181..259 CDD:410795 59/77 (77%)
COG5025 <184..>356 CDD:227358 84/172 (49%)
Required for interaction with TLE6. /evidence=ECO:0000250|UniProtKB:Q60987 249..344 35/95 (37%)
Interaction with KDM5B. /evidence=ECO:0000269|PubMed:12657635 383..406
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 427..455
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 1 1.000 - - otm42140
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2114
SonicParanoid 1 1.000 - - X1751
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.850

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