DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slp1 and Foxd2

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_032619.1	Gene:	Foxd2 / 17301	MGIID:	1347471	Length:	492	Species:	Mus musculus

Alignment Length:	369	Identity:	107/369 - (28%)
Similarity:	148/369 - (40%)	Gaps:	107/369 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ELSASEDFDSPSRTSTPMS--------SAAESLSSQNNDKLDVEF--------DDELEDQLDEDQ 99
            |:.:||  .||:..|.|.:        |....|::::..:...:.        .:|.|..:.||:
Mouse     9 EIMSSE--SSPAALSEPDADIDVVGGGSGGGELTARSGPRAPRDVLPHGHEPPPEEAEADVAEDE 71

  Fly   100 ESEDGNPSKKQKMTA---------------------------------GSDTK----KPPYSYNA 127
            |...|....:.:..|                                 |:.|:    ||||||.|
Mouse    72 EESGGCSDCEPRALAPRGAAAAAGSPGPGVQAARGATGPGPGPGPPSGGAATRSPLVKPPYSYIA 136

  Fly   128 LIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGN 192
            ||.|||..||::||||:.|.:::..||||::.....||||||||||||.||.||||...:|||||
Mouse   137 LITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGN 201

  Fly   193 YWILDPSAEEVFIGETTGKLRRK-------------------------------NPGASRTRLAA 226
            ||.|||.:.::|  :....|||:                               :|||..:..||
Mouse   202 YWTLDPESADMF--DNGSFLRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLSSFAA 264

  Fly   227 YRQAIFSPMMAASPYGAP---ASSYGYPAVPFAAAAAAALYQRMNPAAYQAA----------YQQ 278
            |....:...:|...||||   .:.:.:|.....|.||.|..|...|....||          :..
Mouse   265 YGAYGYGYGLALPAYGAPPPGPAPHPHPHPHAFAFAATAPCQLSVPPGRAAAPPPGPPTASVFAS 329

  Fly   279 MQYQQAPQAHHHQAPHPAQMQGYPQQLNAELFQRMQFFGKFPSS 322
            .....||.......|.||   |.|..|.|||.....|   :|:|
Mouse   330 AASAPAPAPAPGSGPSPA---GLPAFLGAELGCAKAF---YPAS 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	51/84 (61%)
Foxd2	NP_032619.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..125		17/113 (15%)
		Forkhead	129..215	CDD:278670	52/87 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..344		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..441
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920