DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and Foxc1

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_032618.2	Gene:	Foxc1 / 17300	MGIID:	1347466	Length:	553	Species:	Mus musculus

Alignment Length:	263	Identity:	89/263 - (33%)
Similarity:	119/263 - (45%)	Gaps:	79/263 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 DTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKI 181
            |..||||||.|||.||||::|::::|||||||::::|||:::.||:|||||||||||||:||.|:
Mouse    75 DMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKV 139

  Fly   182 PRSYDDPGKGNYWILDPSAEEVFIG-------------------ETTGKLRRKNPGASRTRLAAY 227
            ||....||||:||.|||.:..:|..                   |..|:|..:.|...:    |.
Mouse   140 PRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKGRLHLQEPPPPQ----AG 200

  Fly   228 RQAIFSPMMAASPYGAPASSYG-------------------YPAVPFAAAAA-----AALYQRM- 267
            ||...:|     |..|..|:.|                   .|..|.:.|||     ||...::
Mouse   201 RQPAPAP-----PEQAEGSAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIE 260

  Fly   268 ----------------------NPAAYQAAYQQMQYQQAPQAHHHQA----PHPAQMQGYPQQLN 306
                                  .|.:..||......|.||..||.|.    .....::|.||...
Mouse   261 SPDSSSSSLSSGSSPPGSLPSARPLSLDAAEPAPPPQPAPPPHHSQGFSVDNIMTSLRGSPQGSA 325

  Fly   307 AEL 309
            |||
Mouse   326 AEL 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	53/84 (63%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	1..51
		FH	78..166	CDD:214627	54/87 (62%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250\|UniProtKB:Q12948	78..93		12/14 (86%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250\|UniProtKB:Q12948	168..176		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..326		31/161 (19%)
		Required for transcriptional inhibition. /evidence=ECO:0000250\|UniProtKB:Q12948	217..366		23/112 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..466
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	466..553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820