DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and Foxc2

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_001095150.1	Gene:	Foxc2 / 171356	RGDID:	621703	Length:	494	Species:	Rattus norvegicus

Alignment Length:	290	Identity:	88/290 - (30%)
Similarity:	118/290 - (40%)	Gaps:	109/290 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 AGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCF 178
            |..|..||||||.|||.||||::||:::|||||||::::|||:::.||:|||||||||||||:||
  Rat    65 APKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECF 129

  Fly   179 TKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRKN--------------------PGAS--- 220
            .|:||....||||:||.|||.:..:|  |....|||:.                    |.||
  Rat   130 VKVPRDDKKPGKGSYWTLDPDSYNMF--ENGSFLRRRRRFKKKDVPKDKEERAHLKEPPPASAKG 192

  Fly   221 --------------------RTRLAAYRQAIFSPMMAASPYGA----PASSYGYP---------- 251
                                ::..|:....:.:.:...||.||    |.||...|
  Rat   193 APTGTPVADGPKEAEKKVVVKSEAASPALPVITKVETLSPEGALQASPRSSASTPAGSPDGSLPE 257

  Fly   252 -------------------------------------------AVPFAAAAAAALYQ-------R 266
                                                       |:|:|||..||..|       .
  Rat   258 HHAAAPNGLPGFSVETIMTLRTSPPGGDLSPAAARAGLVVPPLALPYAAAPPAAYAQPCAQGLEA 322

  Fly   267 MNPAAYQAAYQQMQYQQAPQAHHHQAPHPA 296
            ...|.||.:.:.|......:...|....||
  Rat   323 AGSAGYQCSMRAMSLYTGAERPAHVCVPPA 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	54/84 (64%)
Foxc2	NP_001095150.1	FH_FOXC1	66..158	CDD:410818	57/93 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..213		3/46 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..267		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820