DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and Foxd3

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_034555.3	Gene:	Foxd3 / 15221	MGIID:	1347473	Length:	469	Species:	Mus musculus

Alignment Length:	310	Identity:	103/310 - (33%)
Similarity:	135/310 - (43%)	Gaps:	75/310 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PVHHHHQYVHPYSNSDGELSASEDFDSPSR-TSTPMSSAAESLSSQNNDKLDVEFDDELEDQLDE 97
            ||..||....|.:     |:...:...|.. |..|.:...:.                     .|
Mouse    63 PVSAHHGQSQPQA-----LALPTEATGPGNDTGAPEADGCKG---------------------GE 101

  Fly    98 DQESEDGNPSKKQKMTAG-------SDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFP 155
            |..:..|.|......|.|       :...||||||.|||.|||..||:::|||:||.:::.||||
Mouse   102 DAVTGGGGPGAGSGATGGLTPNKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFP 166

  Fly   156 YFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRK----- 215
            |::.....||||||||||||.||.||||...:|||||||.|||.:|::|  :....|||:
Mouse   167 YYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMF--DNGSFLRRRKRFKR 229

  Fly   216 -NPGASRTRLAAYRQAIFSPMMAAS----PYGAP--------ASSYGYPAVPFAAAAAAALYQRM 267
             .....|.:.|...|:..:..:||:    |||.|        |.:|.:||...||||||||
Mouse   230 HQQEHLREQTALMMQSFGAYSLAAAAGAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAAL---- 290

  Fly   268 NPAAYQAAYQQMQYQQAPQAHHHQAPHPAQMQGYPQQLNAELFQRMQFFG 317
                      |..|...|.|       |......|...:.||.::...||
Mouse   291 ----------QYPYALPPVA-------PVLPPAVPLLPSGELGRKAAAFG 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	53/84 (63%)
Foxd3	NP_034555.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		15/89 (17%)
		Forkhead	131..217	CDD:278670	54/87 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950