DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp1 and Foxc2

DIOPT Version :9

Sequence 1:	NP_476730.1	Gene:	slp1 / 33607	FlyBaseID:	FBgn0003430	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_038547.2	Gene:	Foxc2 / 14234	MGIID:	1347481	Length:	494	Species:	Mus musculus

Alignment Length:	205	Identity:	84/205 - (40%)
Similarity:	116/205 - (56%)	Gaps:	29/205 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 AGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCF 178
            |..|..||||||.|||.||||::||:::|||||||::::|||:::.||:|||||||||||||:||
Mouse    65 APKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECF 129

  Fly   179 TKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRKN-------PGASRTRLAAYRQAIFSPMM 236
            .|:||....||||:||.|||.:..:|  |....|||:.       |.....|  |:.:...|...
Mouse   130 VKVPRDDKKPGKGSYWTLDPDSYNMF--ENGSFLRRRRRFKKKDVPKDKEER--AHLKEPPSTTA 190

  Fly   237 AASPYGAPASSYGYPA----VPFAAAAAAAL-----YQRMNP-AAYQAAYQQMQYQQA------- 284
            ..:|.|.|.:.....|    |..:.||:.||     .:.::| .|.||:.:......|
Mouse   191 KGAPTGTPVADGPKEAEKKVVVKSEAASPALPVITKVETLSPEGALQASPRSASSTPAGSPDGSL 255

  Fly   285 PQAHHHQAPH 294
            |: ||..||:
Mouse   256 PE-HHAAAPN 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	FH	120..205	CDD:214627	54/84 (64%)
Foxc2	NP_038547.2	FH	71..159	CDD:214627	56/89 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..213		9/48 (19%)
		EBP50_C	167..>257	CDD:286142	18/91 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..267		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820