Protein Alignment slp1 and FOXO6

DIOPT Version :10

• Sequence 1: NP_476730.1
• Gene: slp1 / 33607
• FlyBaseID: FBgn0003430
• Length: 322
• Species: Drosophila melanogaster
• Sequence 2: NP_001278210.2
• Gene: FOXO6 / 100132074
• HGNCID: 24814
• Length: 559
• Species: Homo sapiens
• Alignment Length: 222
• Identity: 67/222 - (30%)
• Similarity: 104/222 - (46%)
• Gaps: 66/222 - (29%)

  Fly    96 DED--------QESEDGNPSKKQKMTAGSDTKKPP---------------------YSYNALIMM 131
            |||        :.:||..|  :::.||.:....||                     .||..||..
Human    37 DEDGALGAGVAEGAEDCGP--ERRATAPAMAPAPPLGAEVGPLRKAKSSRRNAWGNLSYADLITK 99

  Fly   132 AIQDSPEQRLTLNGIYQYLINRFPYFK-----ANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKG 191
            ||:.:|::||||:.||.:::...||||     .:..||:|||||||||:..|.::..  :..||.
Human   100 AIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQN--EGTGKS 162

  Fly   192 NYWILDPSAEEVFIGETTGKLRRK-----NPGASRTRL---AAYRQAIFSPMMA---ASPYGAPA 245
            ::|:|:|.      |..|||..|:     :.||...|:   |:.::.:.:|..:   :|| .|||
Human   163 SWWMLNPE------GGKTGKTPRRRAVSMDNGAKFLRIKGKASKKKQLQAPERSPDDSSP-SAPA 220

  Fly   246 SSYGYPAVPFAAAAAAALYQRMNPAAY 272
            ..    .||.||..||      :||::
Human   221 PG----PVPAAAKWAA------SPASH 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slp1	NP_476730.1	COG5025	<11..>230	CDD:227358	53/175 (30%)
		Forkhead	120..205	CDD:459732	36/110 (33%)
FOXO6	NP_001278210.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		10/40 (25%)
		FH_FOXO6	89..176	CDD:410837	36/94 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..235		24/88 (27%)
		FOXO_KIX_bdg	358..>382	CDD:465228
		FOXO-TAD	499..537	CDD:435506