DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bowl and SP2

DIOPT Version :9

Sequence 1:	NP_001245861.1	Gene:	bowl / 33602	FlyBaseID:	FBgn0004893	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	XP_011523438.1	Gene:	SP2 / 6668	HGNCID:	11207	Length:	771	Species:	Homo sapiens

Alignment Length:	355	Identity:	85/355 - (23%)
Similarity:	116/355 - (32%)	Gaps:	119/355 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 PPPPPPPSHHREISAFVPV-------LPTGKVR----------------------PGSNSNYEII 131
            |..|..||.:.:|.|..|.       .|:|:|:                      |.|.:.:  :
Human   436 PTVPQKPSQNFQIQAAEPTPTQVYIRTPSGEVQTVLVQDSPPATAAATSNTTCSSPASRAPH--L 498

  Fly   132 AMMADKRKELALRE---------------------AAAAAAMLGRGPGGPGGPGVPPPGVLYGPA 175
            :..:.|.....||:                     ||||.||......|....|||.  .:....
Human   499 SGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPV--TITNTG 561

  Fly   176 GVPPPPY-------LTGPGPSPTGAGSFPFPPGAAAAALFPPG--------LGPGMHAGLDRRLL 225
            |......       ||..|.|||   ........|.|....||        ..|....|..|
Human   562 GQQQLTVQNVSGNNLTISGLSPT---QIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKR--- 620

  Fly   226 RAPGRASRPKKQFICKF--CNRQFTKSYNLLIHERTHTDERPYSCD--ICGKAFRRQDHLRDHRY 286
                ...:.||:.:|..  |.:.|.|:..|..|.|.||.|||:.|:  .|||.|.|.|.|:.|..
Human   621 ----SGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHAR 681

  Fly   287 IHSKEKPFKCTECGKGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYE 351
            .|:.:|.|:|.:|.|.|.:|..|..|                        .||||:|.
Human   682 THTGDKRFECAQCQKRFMRSDHLTKH------------------------YKTHLVTK------- 715

  Fly   352 CSSCGKVFRRNCDLRRHA-LTHAVGEVNSG 380
             :.|   .|:|..|...| ...::||:..|
Human   716 -NFC---LRQNLQLGSSASFVFSLGELGEG 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bowl	NP_001245861.1	COG5048	<232..372	CDD:227381	43/144 (30%)
		C2H2 Zn finger	240..260	CDD:275368	7/21 (33%)
		zf-H2C2_2	252..277	CDD:290200	13/26 (50%)
		C2H2 Zn finger	268..288	CDD:275368	9/21 (43%)
		zf-H2C2_2	280..303	CDD:290200	8/22 (36%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-C2H2	322..344	CDD:278523	4/21 (19%)
		C2H2 Zn finger	324..344	CDD:275368	4/19 (21%)
		zf-H2C2_2	336..361	CDD:290200	6/24 (25%)
		C2H2 Zn finger	352..372	CDD:275368	5/20 (25%)
SP2	XP_011523438.1	COG5048	<553..718	CDD:227381	54/208 (26%)
		zf-C2H2	629..653	CDD:278523	7/23 (30%)
		C2H2 Zn finger	634..653	CDD:275368	6/18 (33%)
		zf-H2C2_2	646..672	CDD:290200	13/25 (52%)
		C2H2 Zn finger	661..683	CDD:275368	9/21 (43%)
		zf-H2C2_2	675..698	CDD:290200	8/22 (36%)
		zf-C2H2	689..711	CDD:278523	9/45 (20%)
		C2H2 Zn finger	691..711	CDD:275368	8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030