DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bowl and ZBTB4

DIOPT Version :9

Sequence 1:	NP_001245861.1	Gene:	bowl / 33602	FlyBaseID:	FBgn0004893	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_001122305.1	Gene:	ZBTB4 / 57659	HGNCID:	23847	Length:	1013	Species:	Homo sapiens

Alignment Length:	1023	Identity:	188/1023 - (18%)
Similarity:	281/1023 - (27%)	Gaps:	424/1023 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GGGLPGAADRNGGSGGSDGGSQNGNGDSRNSSASRISAYETQLAYQQHLAGLHGPPPPPPPSHHR 106
            ||..|..|.....|..|...|.:.:..|..||:|..|:              ..|||..||:...
Human    72 GGAAPNPATTTAASSSSSSSSSSSSSSSSASSSSSSSS--------------SSPPPASPPASSP 122

  Fly   107 EISAFVPVLPTGKVRPGSNSNYEI-IAMMADKRKELALREAAAAAAMLG----RGPGGPGGPGVP 166
            .....:|.:|........|..|.. :|:........|:.|..|....||    :|.|..|...||
Human   123 PRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGEGGDAWVP 187

  Fly   167 PPGVLYGPAGVPPPPYLT--------GPGPSPTG----------------------------AGS 195
            |          .|.|..|        ||||.|.|                            ..|
Human   188 P----------TPAPMATSQPEEDSFGPGPRPAGEWEGDRAEAQAPDLQCSLPRRPLPCPQCGKS 242

  Fly   196 FPFPP-----------GAA---AAALFPPGLGPGMHAGLDRRLLRAP-GRASRPKK--------- 236
            |..|.           ||:   :..|...|.|||..||:|...|..| |....|:.
Human   243 FIHPKRLQTHEAQCRRGASTRGSTGLGAGGAGPGGPAGVDASALPPPVGFRGGPEHVVKVVGGHV 307

  Fly   237 QFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCTECGK 301
            .::|..|.|.:....:|..|...|:..|.|.|..|.|.|...::...|...|:.|:.::|..|.:
Human   308 LYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWE 372

  Fly   302 GFCQSRTLAVHK---------ILHMEESPHKCPVCSRSFNQRSN-LKTHLL--THTDHKPYECSS 354
            .|.....|..|:         :|..|::|      :..:..:.| ||.:.|  .....:||:..|
Human   373 TFVTYYNLKTHQRAFHGISPGLLASEKTP------NGGYKPKLNTLKLYRLLPMRAAKRPYKTYS 431

  Fly   355 CGK--------------------------------------VFRRNCDLRRHALTHAVGEVNSGD 381
            .|.                                      .|.....   ..:.|  |..:||
Human   432 QGAPEAPLSPTLNTPAPVAMPASPPPGPPPAPEPGPPPSVITFAHPAP---SVIVH--GGSSSG- 490

  Fly   382 YVDVGEEDEARNLSGDEEDSLLEVDSPRQ------------------------------------ 410
                |......:..|.:..|::...:|.:
Human   491 ----GGGSGTASTGGSQAASVITYTAPPRPPKKREYPPPPPEPAATPTSPATAVSPATAAGPAMA 551

  Fly   411 ---------------------SPVHNLGESGGSGEKSESER---------------MRLKRKAAI 439
                                 .||..:|  ||.|..:.:.|               :|:..:|.:
Human   552 TTTEEAKGRNPRAGRTLTYTAKPVGGIG--GGGGPPTGAGRGPSQLQAPPPLCQITVRIGEEAIV 614

  Fly   440 DHEESE----------EEFDDFDEEEELQDLPRVHDLPREEDDDFDPEDEEQAEV---------- 484
            ....||          ||.::.:|:||            |||::.:.||||:::.
Human   615 KRRISETDLRPGELSGEEMEESEEDEE------------EEDEEEEEEDEEESKAGGEDQLWRPY 667

  Fly   485 -ALVARFQASKAAATSQSSSSV--GTKPER---------------------QGVTHCHHEGG--- 522
             :...:.:|..|...|...|.:  |.:|.|                     :..|...|..|
Human   668 YSYKPKRKAGAAGGASVGGSGLPRGRRPPRWRQKLERRSWEETPAAESPAGRARTERRHRCGDCA 732

  Fly   523 ETYTMRPHGEKHQEEPGNSGIASLPVPPSFVRYSVP--------------PGAAGPPPAPPGAPP 573
            :|:|......||||..|....:|........|::.|              .|.......|.|.|.
Human   733 QTFTTLRKLRKHQEAHGGGSHSSRAGRRPSTRFTCPHCAKVCKTAAALSRHGQRHAAERPGGTPT 797

  Fly   574 PT----------------HQHPGHPHLLPPNG-------------------DPYL------PILH 597
            |.                .:.|....:...:|                   ||.:      |:
Human   798 PVIAYSKGSAGTRPGDVKEEAPQEMQVSSSSGEAGGGSTAAEEASETASLQDPIISGGEEPPV-- 860

  Fly   598 VRRDLHHKSLNLSKAG---VPPPPHTPPTII---TQPESGK------------------------ 632
                       ::..|   .||....|..:|   .:|..|:
Human   861 -----------VASGGSYVYPPVQEFPLALIGGGREPGGGRGKSGSEGPVGAGEGDRMEGIGAAK 914

  Fly   633 ----PPNQPL-HSPH--EAMP---SFLGSIPMRKRILPAPTLDLMDPHHHPGLGQRTFVDSPSIY 687
                |...|| :.|.  .|.|   |.|.::|:        .|:::.| ...|.|...|:.....|
Human   915 VTFYPEPYPLVYGPQLLAAYPYNFSNLAALPV--------ALNMVLP-DEKGAGALPFLPGVFGY 970

  Fly   688 ALNMSRHPPRQLLGKPPSTETSGATTEKGPPVAAPPIAPPPAPPRRTG 735
            |:|....||                   .||...||..|||.||:..|
Human   971 AVNPQAAPP-------------------APPTPPPPTLPPPIPPKGEG 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bowl	NP_001245861.1	COG5048	<232..372	CDD:227381	33/198 (17%)
		C2H2 Zn finger	240..260	CDD:275368	5/19 (26%)
		zf-H2C2_2	252..277	CDD:290200	9/24 (38%)
		C2H2 Zn finger	268..288	CDD:275368	5/19 (26%)
		zf-H2C2_2	280..303	CDD:290200	5/22 (23%)
		C2H2 Zn finger	296..316	CDD:275368	5/28 (18%)
		zf-C2H2	322..344	CDD:278523	4/24 (17%)
		C2H2 Zn finger	324..344	CDD:275368	4/22 (18%)
		zf-H2C2_2	336..361	CDD:290200	9/65 (14%)
		C2H2 Zn finger	352..372	CDD:275368	3/57 (5%)
ZBTB4	NP_001122305.1	BTB	20..>62	CDD:279045
		BTB	31..>62	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..124		17/65 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..221		12/47 (26%)
		Interaction with CBFA2T3. /evidence=ECO:0000269\|PubMed:23251453	186..348		41/171 (24%)
		zf-C2HC_2	235..257	CDD:290624	3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..281		8/23 (35%)
		C2H2 Zn finger	311..331	CDD:275368	5/19 (26%)
		zf-H2C2_2	323..347	CDD:290200	8/23 (35%)
		C2H2 Zn finger	339..359	CDD:275368	5/19 (26%)
		C2H2 Zn finger	367..385	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..766		53/361 (15%)
		C2H2 Zn finger	728..748	CDD:275368	7/19 (37%)
		C2H2 Zn finger	767..787	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	783..852		9/68 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	883..904		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	972..1013		13/47 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4593
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050