DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bowl and EGR3

DIOPT Version :9

Sequence 1:NP_001245861.1 Gene:bowl / 33602 FlyBaseID:FBgn0004893 Length:744 Species:Drosophila melanogaster
Sequence 2:XP_005273482.1 Gene:EGR3 / 1960 HGNCID:3240 Length:442 Species:Homo sapiens


Alignment Length:464 Identity:108/464 - (23%)
Similarity:153/464 - (32%) Gaps:185/464 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 AAAAVGGGGLP-----------GAADRNGGS-------GGSDGGSQNG----------------- 65
            |.|.||.|..|           .|::|:|.:       |.|.|..:.|                 
Human     5 AGAGVGEGRAPFEGDTLLRSEDKASERSGSATREQRAWGASPGRERRGVLERTGPREEAELCAVE 69

  Fly    66 ------NGDSRNSSASRISA--YETQLAYQQHLA---------GLHGPPPPPPPSHHREISAFVP 113
                  :|.....|.|.:.|  .|.|..:.:..|         ||....|.|..|:.   .:|.|
Human    70 SESPARSGSETTCSCSYLPAPPREEQQCFSRARACVCENVMDIGLTNEKPNPELSYS---GSFQP 131

  Fly   114 ------VLPTGKVRPGSNSNY---EIIAMMADKRKELALREAAAAAAMLGRGPGG---------- 159
                  |...||....|.||:   .||::|              :|.:||..|..          
Human   132 APGNKTVTYLGKFAFDSPSNWCQDNIISLM--------------SAGILGVPPASGALSTQTSTA 182

  Fly   160 -----PGG------PGVPP----------PGVLYGPAGVP-----PPPYLTGPGPS--------- 189
                 |.|      |.:||          |...:.|.|.|     |..|.:.. |:         
Human   183 SMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSAK-PALDSNLFPMI 246

  Fly   190 --------PTGAGSFP-FPP--GAAAAALFPPGLGP--GMHAGLDRRLLRAPGRASRPKKQFIC- 240
                    |...||.| ..|  |.....:.||.:.|  .:.|..|:::  .||..|.|:..... 
Human   247 PDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQI--HPGFGSLPQPPLTLK 309

  Fly   241 -----KFCNRQFTKSYNLLIHERTHTDERPYSC--DICGKAFRRQDHLRDHRYIHSKEKPFKCTE 298
                 |:.||.          .:|...|||::|  :.|.:.|.|.|.|..|..||:..|||:|. 
Human   310 PIRPRKYPNRP----------SKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCR- 363

  Fly   299 CGKGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECSSCGKVFRRNC 363
                                       :|.|||::..:|.||:.|||..||:.|..||:.|.|:.
Human   364 ---------------------------ICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD 401

  Fly   364 DLRRHALTH 372
            :.:|||..|
Human   402 ERKRHAKIH 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bowlNP_001245861.1 COG5048 <232..372 CDD:227381 42/147 (29%)
C2H2 Zn finger 240..260 CDD:275368 3/25 (12%)
zf-H2C2_2 252..277 CDD:290200 7/26 (27%)
C2H2 Zn finger 268..288 CDD:275368 7/21 (33%)
zf-H2C2_2 280..303 CDD:290200 8/22 (36%)
C2H2 Zn finger 296..316 CDD:275368 1/19 (5%)
zf-C2H2 322..344 CDD:278523 7/21 (33%)
C2H2 Zn finger 324..344 CDD:275368 7/19 (37%)
zf-H2C2_2 336..361 CDD:290200 12/24 (50%)
C2H2 Zn finger 352..372 CDD:275368 8/19 (42%)
EGR3XP_005273482.1 DUF3446 142..202 CDD:288757 16/73 (22%)
COG5048 324..>388 CDD:227381 27/91 (30%)
zf-C2H2 330..354 CDD:278523 7/23 (30%)
C2H2 Zn finger 332..354 CDD:275368 7/21 (33%)
zf-H2C2_2 346..371 CDD:290200 12/52 (23%)
COG5048 358..>431 CDD:227381 25/81 (31%)
C2H2 Zn finger 362..382 CDD:275368 8/47 (17%)
zf-H2C2_2 374..399 CDD:290200 12/24 (50%)
C2H2 Zn finger 390..410 CDD:275368 8/19 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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