DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bowl and EGR2

DIOPT Version :9

Sequence 1:	NP_001245861.1	Gene:	bowl / 33602	FlyBaseID:	FBgn0004893	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	XP_011537729.1	Gene:	EGR2 / 1959	HGNCID:	3239	Length:	489	Species:	Homo sapiens

Alignment Length:	397	Identity:	102/397 - (25%)
Similarity:	131/397 - (32%)	Gaps:	156/397 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VGGGGLPGAADRNGGSGGSDGGSQNGNGDSRNSSASRISAYETQLAYQQHLAGLHGPPPPPPP-- 102
            |..|.|.|..     |..|...|.:....|.|..|:......|....|..|..|:.|||||||
Human   129 VSAGILQGVT-----SPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYS 188

  Fly   103 ----SHHREISAFVPVLPTGKVRPGSNSNYEIIAMMADKRKELALREAAAAAAMLGRGPGGPGGP 163
                ..:::.|||:....|.   ..|:..|                            |..|..|
Human   189 GCAGDLYQDPSAFLSAATTS---TSSSLAY----------------------------PPPPSYP 222

  Fly   164 GVPP---PGV------------------LYGPAG--------------VPPP--PYLT------- 184
            ...|   ||:                  |:|.||              ||||  |..|
Human   223 SPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLG 287

  Fly   185 GP-----GPSPTGAGSFPFPPG-------AAAAALFPPGLGPGMHAGLDRRLLRAPGRASRPKKQ 237
            ||     ||..:|....|..||       |||||.:.|     .|..| |.:||.....:||.|
Human   288 GPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNP-----HHLPL-RPILRPRKYPNRPSK- 345

  Fly   238 FICKFCNRQFTKSYNLLIHERTHTDERPYSC--DICGKAFRRQDHLRDHRYIHSKEKPFKCTECG 300
                                 |...||||.|  :.|.:.|.|.|.|..|..||:..|||:|.
Human   346 ---------------------TPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCR--- 386

  Fly   301 KGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECSSCGKVFRRNCDL 365
                                     :|.|:|::..:|.||:.|||..||:.|..||:.|.|:.:.
Human   387 -------------------------ICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDER 426

  Fly   366 RRHALTH 372
            :||...|
Human   427 KRHTKIH 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bowl	NP_001245861.1	COG5048	<232..372	CDD:227381	39/141 (28%)
		C2H2 Zn finger	240..260	CDD:275368	0/19 (0%)
		zf-H2C2_2	252..277	CDD:290200	8/26 (31%)
		C2H2 Zn finger	268..288	CDD:275368	7/21 (33%)
		zf-H2C2_2	280..303	CDD:290200	8/22 (36%)
		C2H2 Zn finger	296..316	CDD:275368	1/19 (5%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	336..361	CDD:290200	12/24 (50%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
EGR2	XP_011537729.1	DUF3446	107..179	CDD:403215	14/54 (26%)
		zf-C2H2	353..377	CDD:395048	8/23 (35%)
		C2H2 Zn finger	355..377	CDD:275368	7/21 (33%)
		COG5048	381..>449	CDD:227381	23/81 (28%)
		C2H2 Zn finger	385..405	CDD:275368	7/47 (15%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030