DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bowl and Egr3

DIOPT Version :9

Sequence 1:NP_001245861.1 Gene:bowl / 33602 FlyBaseID:FBgn0004893 Length:744 Species:Drosophila melanogaster
Sequence 2:NP_061251.1 Gene:Egr3 / 13655 MGIID:1306780 Length:387 Species:Mus musculus


Alignment Length:377 Identity:94/377 - (24%)
Similarity:135/377 - (35%) Gaps:134/377 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 SSASRISAYETQLAYQQHL-AGLHGPPPPPPPSHHREISAFVP------VLPTGKVRPGSNSNY- 128
            |.:|...|:..|:|.:..: .||....|.|..|:.   |:|.|      |...||....|.||: 
Mouse    37 SGSSDSVAHYNQMATENVMDIGLTNEKPNPELSYS---SSFQPAPGNKTVTYLGKFAFDSPSNWC 98

  Fly   129 --EIIAMMADKRKELALREAAAAAAMLGRGPGG---------------PGG------PGVPP--- 167
              .||::|              :|.:||..|..               |.|      |.:||   
Mouse    99 QDNIISLM--------------SAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSN 149

  Fly   168 -------PGVLYGPAGVP-----PPPYLTGPGPS-----------------PTGAGSFP-FPP-- 200
                   |...:.|.|.|     |..|.:.. |:                 |...||.| ..|  
Mouse   150 CGDLYSEPVSFHDPQGNPGLAYSPQDYQSAK-PALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQ 213

  Fly   201 GAAAAALFPPGLGP--GMHAGLDRRLLRAPGRASRPKKQFIC------KFCNRQFTKSYNLLIHE 257
            |.....:.||.:.|  .:.|..|:::  .||..|.|:.....      |:.||.          .
Mouse   214 GMDPIRVNPPPITPLETIKAFKDKQI--HPGFGSLPQPPLTLKPIRPRKYPNRP----------S 266

  Fly   258 RTHTDERPYSC--DICGKAFRRQDHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAVHKILHMEES 320
            :|...|||::|  :.|.:.|.|.|.|..|..||:..|||:|.                       
Mouse   267 KTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCR----------------------- 308

  Fly   321 PHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECSSCGKVFRRNCDLRRHALTH 372
                 :|.|||::..:|.||:.|||..||:.|..||:.|.|:.:.:|||..|
Mouse   309 -----ICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIH 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bowlNP_001245861.1 COG5048 <232..372 CDD:227381 42/147 (29%)
C2H2 Zn finger 240..260 CDD:275368 3/25 (12%)
zf-H2C2_2 252..277 CDD:290200 7/26 (27%)
C2H2 Zn finger 268..288 CDD:275368 7/21 (33%)
zf-H2C2_2 280..303 CDD:290200 8/22 (36%)
C2H2 Zn finger 296..316 CDD:275368 1/19 (5%)
zf-C2H2 322..344 CDD:278523 7/21 (33%)
C2H2 Zn finger 324..344 CDD:275368 7/19 (37%)
zf-H2C2_2 336..361 CDD:290200 12/24 (50%)
C2H2 Zn finger 352..372 CDD:275368 8/19 (42%)
Egr3NP_061251.1 DUF3446 87..147 CDD:314753 16/73 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..283 12/51 (24%)
COG5048 269..>333 CDD:227381 27/91 (30%)
C2H2 Zn finger 277..299 CDD:275368 7/21 (33%)
COG5048 303..>375 CDD:227381 25/81 (31%)
C2H2 Zn finger 307..327 CDD:275368 8/47 (17%)
C2H2 Zn finger 335..355 CDD:275368 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..387 4/8 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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