DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bowl and OSR2

DIOPT Version :9

Sequence 1:NP_001245861.1 Gene:bowl / 33602 FlyBaseID:FBgn0004893 Length:744 Species:Drosophila melanogaster
Sequence 2:NP_001273770.1 Gene:OSR2 / 116039 HGNCID:15830 Length:433 Species:Homo sapiens


Alignment Length:319 Identity:165/319 - (51%)
Similarity:187/319 - (58%) Gaps:55/319 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 SRISAYETQLAYQQHLAGLHGPPPPPPPSHHREISAFVPVLPTGKVRPGSNSNYEIIAMMADKRK 139
            |.:.|..|..|...||.||:|            :|| |..:.......|..:.:||        .
Human   143 SFLQAVNTFPATVDHLQGLYG------------LSA-VQTMHMNHWTLGYPNVHEI--------T 186

  Fly   140 ELALREAAAAAAML-GRGPGGPGGPGVPPPGVLYGP-----AGVPPPPYLTGPGPSPTGAGSFPF 198
            ...:.|.|||..:: .|.|    .|.:|....|:.|     |.|.|..:...|        .|.|
Human   187 RSTITEMAAAQGLVDARFP----FPALPFTTHLFHPKQGAIAHVLPALHKDRP--------RFDF 239

  Fly   199 -----------PPGAAAAALFPPGLGPGMHAGLDRRLL-RAPGRA---SRPKKQFICKFCNRQFT 248
                       ||.....:...||||..: :||.:... |.|.|.   |:.||:||||||.|.||
Human   240 ANLAVAATQEDPPKMGDLSKLSPGLGSPI-SGLSKLTPDRKPSRGRLPSKTKKEFICKFCGRHFT 303

  Fly   249 KSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAVHK 313
            ||||||||||||||||||:||||.||||||||||||||||||||||||.||||||||||||||||
Human   304 KSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHK 368

  Fly   314 ILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECSSCGKVFRRNCDLRRHALTH 372
            .|||:|||||||.|.|:||||||||||||||||.|||.|..||||||||||||||:|||
Human   369 TLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTH 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bowlNP_001245861.1 COG5048 <232..372 CDD:227381 121/139 (87%)
C2H2 Zn finger 240..260 CDD:275368 17/19 (89%)
zf-H2C2_2 252..277 CDD:290200 22/24 (92%)
C2H2 Zn finger 268..288 CDD:275368 18/19 (95%)
zf-H2C2_2 280..303 CDD:290200 21/22 (95%)
C2H2 Zn finger 296..316 CDD:275368 17/19 (89%)
zf-C2H2 322..344 CDD:278523 18/21 (86%)
C2H2 Zn finger 324..344 CDD:275368 16/19 (84%)
zf-H2C2_2 336..361 CDD:290200 20/24 (83%)
C2H2 Zn finger 352..372 CDD:275368 16/19 (84%)
OSR2NP_001273770.1 COG5048 <293..428 CDD:227381 120/135 (89%)
C2H2 Zn finger 295..315 CDD:275368 17/19 (89%)
zf-H2C2_2 307..332 CDD:290200 22/24 (92%)
C2H2 Zn finger 323..343 CDD:275368 18/19 (95%)
zf-H2C2_2 335..358 CDD:290200 21/22 (95%)
C2H2 Zn finger 351..371 CDD:275368 17/19 (89%)
zf-C2H2 377..399 CDD:278523 18/21 (86%)
C2H2 Zn finger 379..399 CDD:275368 16/19 (84%)
zf-H2C2_2 391..416 CDD:290200 20/24 (83%)
C2H2 Zn finger 407..427 CDD:275368 16/19 (84%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11341
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000748
OrthoInspector 1 1.000 - - mtm8449
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14196
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
66.040

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