DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bowl and Osr2

DIOPT Version :9

Sequence 1:	NP_001245861.1	Gene:	bowl / 33602	FlyBaseID:	FBgn0004893	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_001355594.1	Gene:	Osr2 / 107587	MGIID:	1930813	Length:	312	Species:	Mus musculus

Alignment Length:	321	Identity:	168/321 - (52%)
Similarity:	189/321 - (58%)	Gaps:	59/321 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SRISAYETQLAYQQHLAGLHGPPPPPPPSHHREISAFVPVLPTGKVRPGSNSNYEIIAMMADKRK 139
            |.:.|..|..|...||.||:|            :|| |..:.......|..|.:||        .
Mouse    22 SFLQAVNTFPAAVDHLQGLYG------------LSA-VQTMHMNHWTLGYPSVHEI--------T 65

  Fly   140 ELALREAAAAAAML-GRGPGGPGGPGVPPPGVLYGP-----AGVPPPPYLTGPGPSPTGAGSFPF 198
            ...:.|.|||..:: .|.|    .|.:|....|:.|     |.|.|..:...|        .|.|
Mouse    66 RSTITEMAAAQGLVDARFP----FPSLPFATHLFHPKQGAIAHVLPALHKDRP--------RFDF 118

  Fly   199 -----------PPGAAAAALFPPGLGPGMHAGL-----DRRLLRAPGR-ASRPKKQFICKFCNRQ 246
                       ||.....:...||||..: :||     ||:..|  || .|:.||:||||||.|.
Mouse   119 ANLAVAATQEDPPKMGDLSKLSPGLGSPI-SGLSKLNPDRKPSR--GRLPSKTKKEFICKFCGRH 180

  Fly   247 FTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAV 311
            ||||||||||||||||||||:||||.||||||||||||||||||||||||.||||||||||||||
Mouse   181 FTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAV 245

  Fly   312 HKILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECSSCGKVFRRNCDLRRHALTH 372
            ||.|||:|||||||.|.|:||||||||||||||||.|||.|..||||||||||||||:|||
Mouse   246 HKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTH 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bowl	NP_001245861.1	COG5048	<232..372	CDD:227381	121/139 (87%)
		C2H2 Zn finger	240..260	CDD:275368	17/19 (89%)
		zf-H2C2_2	252..277	CDD:290200	22/24 (92%)
		C2H2 Zn finger	268..288	CDD:275368	18/19 (95%)
		zf-H2C2_2	280..303	CDD:290200	21/22 (95%)
		C2H2 Zn finger	296..316	CDD:275368	17/19 (89%)
		zf-C2H2	322..344	CDD:278523	18/21 (86%)
		C2H2 Zn finger	324..344	CDD:275368	16/19 (84%)
		zf-H2C2_2	336..361	CDD:290200	20/24 (83%)
		C2H2 Zn finger	352..372	CDD:275368	16/19 (84%)
Osr2	NP_001355594.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..165		7/21 (33%)
		C2H2 Zn finger	174..194	CDD:275368	17/19 (89%)
		zf-H2C2_2	186..211	CDD:338759	22/24 (92%)
		C2H2 Zn finger	202..222	CDD:275368	18/19 (95%)
		zf-H2C2_2	214..237	CDD:338759	21/22 (95%)
		C2H2 Zn finger	230..250	CDD:275368	17/19 (89%)
		COG5048	251..>312	CDD:227381	47/56 (84%)
		C2H2 Zn finger	258..278	CDD:275368	16/19 (84%)
		C2H2 Zn finger	286..306	CDD:275368	16/19 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11278
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000748
OrthoInspector	1	1.000	-	-		mtm8689
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.040