DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bowl and znf281a

DIOPT Version :9

Sequence 1:	NP_001245861.1	Gene:	bowl / 33602	FlyBaseID:	FBgn0004893	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	XP_001922388.3	Gene:	znf281a / 100005963	ZFINID:	ZDB-GENE-131126-34	Length:	849	Species:	Danio rerio

Alignment Length:	831	Identity:	173/831 - (20%)
Similarity:	265/831 - (31%)	Gaps:	299/831 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SDGGSQNGNGDSRNSSASRISAYETQLAYQQHLAGLHGPPPPPPPSHHREISAFVPVLPTGKVRP 122
            |:||.:.|.|.|              :....||        ||..|..|..|..|    ..:::|
Zfish    15 SNGGMEPGFGAS--------------MLMFSHL--------PPVTSFTRLASQTV----MAELQP 53

  Fly   123 GSNSNYEIIAMMADKRKELALREAAAAAAMLGRGPGG-PGGPGVPPPGVLYGPAGVPPPPYLTGP 186
                 :|:|.     :||   |::....|..|...|| ..|.|:   |.:.|..|    .|:...
Zfish    54 -----HEMIL-----KKE---RDSPDCGAGGGLNTGGMVAGGGI---GGMMGNVG----DYVHAM 98

  Fly   187 GPSPTGAGS----FPFPPGAAAAALFPPGLGPGMHAG-----------------------LDRRL 224
            |........    .|..||.        |.|.|:.:|                       |..||
Zfish    99 GIKQEKVSEHDYRLPLYPGT--------GTGAGVRSGGELLEVSLGNHQNLVVHDLSLGNLSGRL 155

  Fly   225 L---------RAPGRASRPKKQFICKFCNRQFTKSYNLLIHE---RTHTDERPYSCDICGKAFRR 277
            :         |:.|.....|.:       |:..:|.::::..   ....:.:|:.|:.|..|||.
Zfish   156 VKESSGRKGRRSNGEGQEAKTR-------RKRGESKSMMLDPDGGSLSPNSKPHICEHCNAAFRS 213

  Fly   278 QDHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLL 342
            ..|||.|..||:.|:||:||:|...|.|...|..|:.:|..|.|..|..|:..|.|:.:::.|..
Zfish   214 SYHLRRHVLIHTGERPFRCTQCNMSFIQKYLLQRHEKIHSGEKPFSCDQCNMRFIQKYHMERHKR 278

  Fly   343 THTDHKPYECSSCGKVFRRNCDLRRHALTHAVGEVNSGDYVDVGEE--DEARNLSGDEED---SL 402
            ||:..|||:|.:|.:.|.|...|.:|..|       .||.:..|.:  |.....:||.|.   .:
Zfish   279 THSGEKPYKCDTCQQYFSRTDRLLKHKRT-------CGDAIKKGLDGADHELGSAGDTEHGSYGI 336

  Fly   403 LEVDSPRQSPVHNLGESGGSGEKSESERMRLKRKAAIDHEESEEEFDDFDEEEELQDLPRVHDLP 467
            .:.::|  :|....|:|...||..|.:|.:......:.|.:..:.:.             |||.
Zfish   337 SQGNTP--TPARKRGKSKTPGEGGERKRKKASGPMGMQHSQGVDGYG-------------VHDF- 385

  Fly   468 REEDDDFDPEDEEQAEVALVARFQASKAAATSQSSSSVGTKPERQGVTHCHHEGGE--------- 523
                                     ..|.....|::|...:|:    .:.|.|.|:
Zfish   386 -------------------------GSAVNHGASTTSASAQPD----PNIHTEHGQSPKMALKKG 421

  Fly   524 --------TYTMRPHGEKHQEEPGNSGIASLPVPPSFVRYSVPPGA-AGPPPAPPGAPPPTHQHP 579
                    |:.|.....:..|.|...|:.||.:.|.       ||| .|  |:..|:
Zfish   422 NRKSLEKTTHPMVHSKPEDMELPSGGGLDSLGLLPG-------PGAKVG--PSSSGS-------- 469

  Fly   580 GHPHLLPPNGDPYLPILHVRRDLHHKSLNLSKAGVPPPPH------TPPTIITQPESG------- 631
                    |.|..:..|..||.|:  ..|...||.....:      :.||:.....||
Zfish   470 --------NYDDAMQFLKKRRYLN--VTNSGSAGSGASDYDVSHLQSQPTVNQGVVSGVLDSDGT 524

  Fly   632 ------------KPPNQPLHSPHEAMPSFLGSIPMRKRILPAPTLDLMDPHH---HPG------- 674
                        ||....:  |.|.:.|.|.....:    |..:.|:.|.||   .|.
Zfish   525 LSLLDASSLVDIKPDKSGI--PDEVLQSLLDHYAHK----PDVSFDIPDHHHVELQPAAPDATDP 583

  Fly   675 LGQRTFVDSPS---------------IYALNMSRHPPRQLLGKPPSTETSGATTEKGP------- 717
            ||......||:               :.||..:.|....:||......|:|......|
Zfish   584 LGPEDNPSSPNSGDKAVIMHEYSRFLLQALERTSHSASFVLGPGSGVTTTGPFPGTSPLLSDKHV 648

  Fly   718 ------------PVAAPP---------------IAPPPAPPRRTGFSIEDI 741
                        ||::.|               .:|||      ||.:..:
Zfish   649 YTSSPLEYSFSHPVSSSPSLSSVPKSHFGLLEGSSPPP------GFHLSSL 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bowl	NP_001245861.1	COG5048	<232..372	CDD:227381	44/142 (31%)
		C2H2 Zn finger	240..260	CDD:275368	2/22 (9%)
		zf-H2C2_2	252..277	CDD:290200	5/27 (19%)
		C2H2 Zn finger	268..288	CDD:275368	9/19 (47%)
		zf-H2C2_2	280..303	CDD:290200	12/22 (55%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-C2H2	322..344	CDD:278523	5/21 (24%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	336..361	CDD:290200	9/24 (38%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
znf281a	XP_001922388.3	COG5048	<194..>292	CDD:227381	36/97 (37%)
		zf-C2H2	202..224	CDD:278523	9/21 (43%)
		C2H2 Zn finger	204..224	CDD:275368	9/19 (47%)
		zf-H2C2_2	216..241	CDD:290200	13/24 (54%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		zf-H2C2_2	245..269	CDD:290200	8/23 (35%)
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		zf-H2C2_2	272..297	CDD:290200	9/24 (38%)
		C2H2 Zn finger	288..307	CDD:275368	6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4522
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960