Protein Alignment CG43707 and kmr

DIOPT Version :10

• Sequence 1: NP_001260005.1
• Gene: CG43707 / 33601
• FlyBaseID: FBgn0263846
• Length: 2021
• Species: Drosophila melanogaster
• Sequence 2: NP_001097775.2
• Gene: kmr / 5740131
• FlyBaseID: FBgn0085412
• Length: 3090
• Species: Drosophila melanogaster
• Alignment Length: 2300
• Identity: 405/2300 - (17%)
• Similarity: 690/2300 - (30%)
• Gaps: 937/2300 - (40%)

  Fly   144 QNSYTDTHELESSYFRRQPA-SILSTGKSGEADLGGRYTWIGQQQVTNNNP-------------- 193
            :||.:..|.|:|...:.||. |..:||.||    ||  :..||....|..|
  Fly   492 ENSDSGIHTLQSHPGKGQPTPSSENTGSSG----GG--SGSGQPLYANAPPKPRRINDGGYSSPS 550

  Fly   194 ----DYQSDHSSYH--CPTYATMPTTHHQHHHQQQGG---------NVRTKHVSFA----RSHTL 239
                :.|..|.|..  .||........||...|||..         :.||.|||.|    ::...
  Fly   551 PEHNEQQQQHPSRRLMSPTQQLYQQQQHQRSQQQQQQQPQQHHAIYDTRTGHVSTALQLQQAQQQ 615

  Fly   240 TSFDNVNAGFRSS--------GRLKTARSQERLIGGKKPIIA--------TGSMYETLQPPLQVQ 288
            .|.|::.|.|:..        .||:..|:.|.:.|.::..:|        ....|.|.|..||.:
  Fly   616 YSLDHLEAQFQQQQLDMEEQIARLQQQRAAEEIYGEREMYMAKLMQQRQGPNGTYPTQQQLLQAE 680

  Fly   289 QQ--------------------------------------PQQMQP---QQSSTLPKTWLPPP-- 310
            ::                                      |...|.   |::::..:...||.
  Fly   681 RRTPDAYGRSKQQRLFAAAAAAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYD 745

  Fly   311 ----VQLQPCQHHHAPIHLHQPISDNMVGLIIPQPLPLALPLPSPEVLIVEKKFRNAMKTQATQT 371
                |...|  ..:.|.||....:|.::..:..:....|        .||.....:.::.:|...
  Fly   746 GSKHVPAMP--QRYTPNHLEASAADQLINTMDLRARTAA--------AIVRPHSADFLEYEARAE 800

  Fly   372 DAAARRQGQLGYNTQVLALSPRPPHRIKV--------VSQGAQTNGLQNGKKLTKSLSEIPNGKD 428
            .|||.....:..:.|....:|||...:.:        .|:.:..:      |:.||...:.:|..
  Fly   801 AAAAAAAAAVAQSQQESGRAPRPKSSLDINRTPDSFYYSEASYAD------KMRKSALYLQSGGA 859

  Fly   429 GTSSHHYQQGSIYPHEMIYRTQSQDVTPLQTLSDAQNNIMY-------YKPPPPLLDAHSYGL-G 485
            | ::...|.||       |||...|      .:...|.|.|       ||....|.:|...|. .
  Fly   860 G-AAQPQQPGS-------YRTTGAD------FNSGVNTIGYENPYERAYKRQELLAEAQGGGASS 910

  Fly   486 MEHLSRTR----------PSPSEQNVEYVNVNAAA-----------VALNESFDYESNS-LPRRA 528
            |..:||:.          .||.::::..:||:..:           ::.||.|...::: ||:|:
  Fly   911 MPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFPPSMSTQEIISKNEQFLRSASARLPKRS 975

  Fly   529 CTSHTDF---------------YSNS-----------------------------LPRRHITESS 549
            .....|:               .|||                             |.|:.|.:..
  Fly   976 GGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESMKRLLEWKQRMLQSPLTRKGIQQGG 1040

  Fly   550 ELMTDSVPLDFSQSHLLP--------------------------------PPS------------ 570
            ..|:....|..:.:.||.                                |||
  Fly  1041 SNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVLVGNGNGTAQGAGNPPSASGIQRSRSESQ 1105

  Fly   571 -----------EYCKNDDE----DVEEYY------------------------------------ 584
                       .| .:|||    |.:..|
  Fly  1106 ANVGPGGVVYNNY-SSDDEAGTVDDDNLYSATAGRSSSSKTTTKATTSQAIVATTTAALAITNLG 1169

  Fly   585 -DEDEDHPHETE-----SYSSEVC-------------MEQAAQHRRMSMLPQMIDSPFRRDDLRR 630
             .::.:.|::||     |.||...             :.:|::.|.:.:.|:.::   .|..||.
  Fly  1170 SSKNLETPNQTETEATPSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQPKHLE---ERPKLRL 1231

  Fly   631 QSMPVYGQTEKLIDGFGPRSSFRRRDKVSCFPDEPPAVQEVRDEQEIFIDFKP-HISP------- 687
            |.....|..|:                           |:..||::..::.:| .|.|
  Fly  1232 QLPKAMGNEEE---------------------------QKQEDEEQENVEAEPVPILPKKTAPKS 1269

  Fly   688 ------------------------KPSPKLQLKHR----------------KQHKAEIAMRKMQQ 712
                                    ||.|:.::.|.                |..|.:...:|.||
  Fly  1270 PQNANYVPVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFKEQQDQQKQQQ 1334

  Fly   713 QRMAQAAALTLPKPKSQPVEVE--------VRKVELEPSDEE---EDEDEVSEPEEEDDGEEIDD 766
            :.  :...|| |..:|:|:..|        ::..:||.::||   ||||:.:..||..|    ||
  Fly  1335 EN--EEEDLT-PTAESKPIPGEEDMGAPKVIKDQKLESNEEEQELEDEDDSTACEEYTD----DD 1392

  Fly   767 DEQKLETDLQEDEEPLYENITPCGCRVVPTSDAEDIQDKRSQFRKRSVSLDDDYEAKASETPTPT 831
            .::.|..| .|||            .||...:::::.::|        .|...|   .:|..|||
  Fly  1393 IDEALAQD-DEDE------------AVVEAVESQELAEER--------ELQQIY---VNEPITPT 1433

  Fly   832 GLRLPST---PASPCRDEL-----LANVS-TYPSSDSLANDNTRDH----SDGIWNES------- 876
            ..:...:   |.:|.:.||     |..|| ||      |.:...:|    :.||.:|.
  Fly  1434 DQQFDESHYLPMTPKKVELGQPGVLTLVSATY------AEEEEENHYVEMTKGIQDEDCRSNYEI 1492

  Fly   877 -----------QVTVLT------------------AEQRDISDGSYSSNLLLTPSSKRKNLLLQH 912
                       :||..|                  .|:...|.|  .|.|.....|..:.|..:.
  Fly  1493 MCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSG--RSTLKKCKKSGTETLKKKT 1555

  Fly   913 QQRSSVD---------------TDALDFEEQSPTYGLQT--LPKIIKTPTPTTSRP--------- 951
            ::|...|               :|:.|.:::|....|:.  |....:.....|.||
  Fly  1556 KKRQGKDMPDILKPAKSALALASDSSDADDESSRQQLEAKKLRSRSRFSLSDTFRPASYYLGAST 1620

  Fly   952 -------TSTQPMMPPPAIAVTP------STNQILDS---------------------------- 975
                   :|...::|||.|..:|      .|.:|..|
  Fly  1621 PLNNYAESSDSEILPPPPIPASPPPMEELKTEEIFSSEHYDTVKRKDSNGKVNLSYEQLPKMHAS 1685

  Fly   976 --------CISSPLPKRSMVARGSVPD--------ARQLMFTSGATKQRH----SDASFLPMGAA 1020
                    .:.||..|.|   |.|:||        .::|:..:...:|.|    ||:::
  Fly  1686 NTSLNLPKAVPSPTLKSS---RLSLPDHFTKVRMTPQRLLVPATPPQQHHARTLSDSNY------ 1741

  Fly  1021 DYARSADISECSTNTD----------EYATCTDTSKRTPVSTQSSQLE------------KTHAG 1063
                |..:::.|:.|.          :...|| ::...|:|:::..:|            ::...
  Fly  1742 ----SCQLTDTSSRTSSDLDLYRRRGQQQRCT-SNNSLPLSSENESVEFRQRSDSELDRQRSRRP 1801

  Fly  1064 SSFESASSLYSMREDLLQHDEKERDKQTTLTKAQLKSPIGSVAELTRKS--PSHSISSTTSSGSC 1126
            .|.||.|.:.|:.|   |.:|       ||:..:|.:.:..:...|.::  .||.::...::...
  Fly  1802 LSQESISEIESLSE---QFEE-------TLSSHELDTYLSHLHLSTGQATPTSHLLNDANAAAGA 1856

  Fly  1127 PVLGAAIKSPA----KESLPQTVASSVTSQMKVSSVECIPPGVKPKPDSISEDERSEVRYSSSGY 1187
            .:|...||.|.    .|...|....::.......|::.:..........|.....|.:...|:.|
  Fly  1857 DILTNLIKPPKTFRNAEDEEQHFYGNIHFLSSTDSIQQLGEAGATALRIIHSRNNSNISTQSAPY 1921

  Fly  1188 YESP--------HEED--------------------------DEEQGTRSKARRLRQED-----E 1213
            |.|.        ::.|                          |::|...||.....|:|     .
  Fly  1922 YYSELPAPPPLNNQRDIHAHGLNIAHIHNPIDRHQFNVDALVDKDQAIDSKNIYCGQKDNNEKLS 1986

  Fly  1214 RKRRKTSMKLDIEKE-----NMRALTSPI--------------KKPTGSSKIT---SPEQSISG- 1255
            .|..|.:..:|:..|     :.....:|:              :|..|.|..:   :|.:..:|
  Fly  1987 NKNLKLNKSVDLPAEMEGSGSSGGALNPVVHSYLTTTKNTNLARKTIGGSNPSDDGNPNEDGAGE 2051

  Fly  1256 -TMDNGSSPSKMKRFRPKI-------------RRQLRKSSREDVLAAAAVRRSRATPTIFGLSSG 1306
             |.:.|.:||........:             |..||:.|:....:...:.|..|.|.|......
  Fly  2052 NTEEAGKTPSNNVHTNLSVLGGELLWEEDALWRESLRRVSQRHARSLDDLDRITAAPPISSTPKA 2116

  Fly  1307 SGDTEL------------------------LLDASMSTGAVAGTTTSAVTSVSAPSSASKLPTSE 1347
            ....|:                        |:|.: |:......|.|.|..|....:||.|....
  Fly  2117 KLSREVTYVNDSLKPRQHPHITNEHDVYVQLMDTT-SSSHDHDQTDSDVYEVLREETASNLSHKS 2180

  Fly  1348 SSV----TTQPEAVVAPLPAKKPHSCATPTSLLSPKLPTTSGTQS------KSTSD--------T 1394
            :.:    ..|.:|:.:.| .|..||....|...|..||.||..:|      .|:.|        |
  Fly  2181 NELDRETIRQWDAMSSGL-MKSNHSGVEATGASSAHLPLTSSVRSIVQQLNNSSMDDANGNPMAT 2244

  Fly  1395 FQLKAKSIESL----RSVSPGSDSV--------FYSEA---------------------DGNAAS 1426
            ..:..:::.:|    .:|.|....|        :|..|                     .|.|.|
  Fly  2245 ASISVRNVNNLPVGNLTVKPDPSDVHQESAFAPYYGGAAETKYAKNTVLTDRGLYAANGSGLATS 2309

  Fly  1427 GEQSH----CHHCGKEME--------GKQQSNTISELAG----DSVESIPYIEQDIV-------- 1467
            ..|:|    ..|.|...|        ..|..|.:....|    :|::.:.|::|.::
  Fly  2310 TPQNHQQFRMRHTGSRAEIDMLERETSSQIRNRLRSAEGLTRAESIQRLDYLKQHLLDLERHYEK 2374

  Fly  1468 -KPPSDFADSPVTTKTTQRLYKKMDKRFRSEERYHGERGRHYKTRQENIRAKSEERGRIPSLPNT 1531
             ||..:..|:.|          |:...:|                       ::..||:
  Fly  2375 SKPLVNLVDNMV----------KLGSLYR-----------------------NDANGRV------ 2400

  Fly  1532 PVLRPAGSSPCVLPDTEQSQHIIYKGHYDAGRYTRLTDDDLWTQLDHQCFDRSRERRASTESEKG 1596
                    .|..|...|.:|              |:.:..:..:...|.     ||.:..::|..
  Fly  2401 --------QPATLDRLEFNQ--------------RMQEQQMLQEEQQQW-----ERLSPNQAELQ 2438

  Fly  1597 FHAKYQVILHRLVQRRC-TLEMYHRQK--------------HNSFLWAKCKEISAKSFRNIFAVF 1646
            ....||  |.:|:|... ||:...|.|              |:|.......|.:.|...    :.
  Fly  2439 VRELYQ--LDQLLQEESGTLQSLQRDKEDLERALGGLRARIHDSNATPMALEAAKKQQH----IL 2497

  Fly  1647 TQYSGQMIELIASNSTPDSIRRKLEEVL-------KLMLLVWARESYVISKLSNGAHGVDKTVVV 1704
            .:...::.:|:|.||      :|||:.:       :.:||:..:...|....:||.:|
  Fly  2498 ERELSRVHQLLAENS------KKLEQTVAGNARLEQELLLLRQKVQAVRGSTTNGMNG------- 2549

  Fly  1705 KSDSGEFGFRIHGSKPVVVAAIEPE 1729
                  .|..|:|.:...|.|.|.|
  Fly  2550 ------DGSHINGDQTAAVLASELE 2568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	99/564 (18%)
		PDZ	1700..1776	CDD:214570	6/29 (21%)
		PH-like	1792..1893	CDD:473070
		PH-like	1911..2011	CDD:473070
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068