Protein Alignment CG43707 and plekha6

DIOPT Version :10

• Sequence 1: NP_001260005.1
• Gene: CG43707 / 33601
• FlyBaseID: FBgn0263846
• Length: 2021
• Species: Drosophila melanogaster
• Sequence 2: XP_073772778.1
• Gene: plekha6 / 568764
• ZFINID: ZDB-GENE-140106-14
• Length: 1177
• Species: Danio rerio
• Alignment Length: 1366
• Identity: 261/1366 - (19%)
• Similarity: 412/1366 - (30%)
• Gaps: 499/1366 - (36%)

  Fly   410 LQNGKKLTKSLSEIPNGKDGTSSHHYQQGSIYPHEMIYRTQSQDVTPLQTL--SDAQNNIMYYK- 471
            |:.||:....    |||..|             |:.:.:|..::..||:.|  ||.:.|   .|
Zfish     6 LEEGKRSQND----PNGTVG-------------HQQVIQTHLEENGPLKALLSSDLEMN---GKA 50

  Fly   472 ----PPPPLLDAHSYGLGMEHLSRTRPSPSEQNVEYVNVNAAAVALNESFDYESNSLPRRACTSH 532
                |.....:|:|.|..:..:|...|......                   .....|:||.|..
Zfish    51 GGRGPVNKASEANSNGNNLSMVSEVPPDGQNHT-------------------RGTRTPKRAATFG 96

  Fly   533 TDFYSNSLPRRHITESSELMTDSVPLDFSQSHLLPPPSEYCKN--------DDEDVEEYYDEDED 589
            .  .|||:.|....|.|.           |..|....|...|.        .|..:..|.||.|:
Zfish    97 K--RSNSMRRNPNAEVSR-----------QGWLYKQASSGVKQWNKRWFVLTDRCLFYYKDEKEE 148

  Fly   590 HPHETESYSSEVCMEQAAQHRRMSMLPQMIDSPFRRDDLRRQSMPVYGQTEKLIDGFGP---RSS 651
                                                        .|.|....|....||   ..|
Zfish   149 --------------------------------------------GVLGSLPLLSFKIGPVQTSDS 169

  Fly   652 FRRR--DKVSCFPDEPPAVQEVRDEQEIFIDFKPHISPKPSPKLQLKH---RKQHKAEIAMRKMQ 711
            ..|:  .||.|      ..:|..:|:|...|.|..|    :..||::|   |..:.:..:.::.:
Zfish   170 ITRKFAFKVWC------ETEEEEEEEEESEDLKGSI----AFCLQVEHAGTRTYYFSADSQKEQE 224

  Fly   712 Q--QRMAQAAAL---TLPKPKSQPV----EVEVRKVELEPSDEEEDE---DEVSEP-EEEDDGEE 763
            :  |.|::||.:   |.|:.||.|:    :.::....|||....|:.   .::.|| :.|.:|.|
Zfish   225 EWIQAMSEAARVHIPTTPRSKSNPIPAADQNDMVAKRLEPKSHAENNGQCPDLHEPVKHELNGLE 289

  Fly   764 IDD----------------------------------------DEQKLETDLQEDEEPLYENITP 788
            ..|                                        ...:.:.::::..||:.||:.
Zfish   290 TRDTTPSTPVTPVTPNTDGRMGEKGGLGPHHPNGWGNYGPPNGSRYQSQENVRDMREPMDENVV- 353

  Fly   789 CGCR--VVPTSDAEDIQDKRSQF---------RKRSVSLDD----------------DYEAKASE 826
              .|  .||.:..|.:..::|..         |:..|..||                ||......
Zfish   354 --MRRGFVPRTAPERLAQRKSSMTQLQQWVNQRRALVPQDDGRSPSRYYTVNRGMPADYYGVYGG 416

  Fly   827 TP-------TPTGLRLPSTPASPC----------------------RDELLAN------------ 850
            .|       .|.|:|    |.|.|                      ||..|..
Zfish   417 APYVDEYPLYPPGVR----PESICSMSAAYNRPSPRWTVEERRRSLRDGPLYGQPRDPQWMMGPQ 477

  Fly   851 -VSTYPSSDSLANDNTR-----------------------DHS---------------------D 870
             .|.||..||..|...|                       .||                     :
Zfish   478 APSYYPQLDSAQNSMRRLSIQPRSRSVPRSPSSSSGGPYSPHSFASPARSPSARFDRGPARIRDE 542

  Fly   871 GIWNESQVTVL-----------TAEQRDISDGSYSSNLLLTPS--SKRKNLLLQHQQRSSVDTDA 922
            ||:.:..|..|           ..::|..|.|.|..|...:||  ||.:::|....||:
Zfish   543 GIYADPSVYGLRRSMSSPKYDFPGDRRSYSQGMYQYNYPASPSLHSKMEDILDAQLQRN------ 601

  Fly   923 LDFEEQS------------PTYGLQTLP------------KIIKTPTPTTSRPTSTQPMMPPPAI 963
            ||:.:|.            ||..|..:.            :::|.......|....:..:.
Zfish   602 LDYLDQQVPPFHEVYGDLHPTLKLNEIETSKLLGRLCEQNRLLKEQETVVHRLRMEKDSLE---- 662

  Fly   964 AVTPSTNQILDSCISSP-------LPKRSMV-----ARGSVPDARQLMFTSGATKQRHSDASFLP 1016
            .|..:|:|.::...:.|       |.|.|:.     .||.:..|...:.|:....:...|
Zfish   663 GVLVATHQEMELYRNQPLVMEKLQLKKESLQNKLINIRGELSQASSALTTTRVEFEALED----- 722

  Fly  1017 MGAADYARSADISECSTNTDEYATCTDTSKRTPVSTQSSQLEKTHAGSSFESASSLYSMREDLLQ 1081
                               |..|...|..::.....| |:|...|....|...       :|:|:
Zfish   723 -------------------DVNAIHGDLWEQLNAGGQ-SELVHRHIQKEFWRV-------QDVLE 760

  Fly  1082 HDEKERDKQTTLTKAQLKSPIGSVAELTRKSPSHSISST--TS--SGSCPVLGAAIKSPAK---- 1138
            ...|....:.|.| |:.:...|:....:..||:..:||.  ||  |...||.|:. .||.|
Zfish   761 GLHKNNPSRGTDT-AKHRVASGASGSFSTNSPASPLSSVSLTSPLSPFSPVPGSQ-PSPTKHLAT 823

  Fly  1139 -ESLPQTVASSVTSQMKVSSVECIPPGVKPKPDSISEDERSEVRYSSSGYYESPHEEDDEEQGTR 1202
             |::|.. .....|...:.|.:..||.|.|.|...:..:||..|  :||.::..:::|.:   ..
Zfish   824 EEAIPPR-PPLPKSYQPLESSQSFPPSVPPLPLDSNAWQRSMGR--NSGIHQEGYKDDGD---FH 882

  Fly  1203 SKARRLRQEDERKRRKTSMKLDIEKE-------NMRALTSP-IKKPTGSSKITSPEQSISGTMDN 1259
            |:......:.|    |||   |.|.|       |...:..| .|.|:.....:...|..:|.:.|
Zfish   883 SRKHNYNSQGE----KTS---DFETEQDRLSNQNKVGIVPPRTKSPSEEKNNSDAVQRRNGKVPN 940

  Fly  1260 GSSPSKMKRFRPK--------------------IRRQLRKSSREDVLAAAAVRRSRATPTIFGLS 1304
            |    .:.|.|||                    |||....|.|:.       |||      ..||
Zfish   941 G----HISRERPKSAVFPAEVKSKMSVEEQNERIRRNQSSSVRDK-------RRS------LNLS 988

  Fly  1305 SGSGDTELLLD---ASMSTGAVAGTTTSAVTSVSAPSSASKLPTSESSVTTQPEAVVAPL--PAK 1364
            |...     :|   :|.|...|....|:....:....:|.:....||     |...:|.|  ..:
Zfish   989 SNQH-----IDGFKSSTSYRVVRRRVTADEVDIKGLEAAVRGEGMES-----PREEIARLRRQVE 1043

  Fly  1365 KPH-------SCATPTSLLSPKLPTTSGTQSKSTSDTFQLKAKSIESLRSVSPGSD-----SVFY 1417
            ..|       ..:.|..:|.|:........:..:.:..:.|.|.:|.::::...|:     .|..
Zfish  1044 PEHYDLDLSKELSMPDKVLIPERYLDMEPNTPLSPEELREKQKKVERIKTLIAKSNLQNVVPVLD 1108

  Fly  1418 SEADGNAASGEQSHCHH------CGKEMEGKQQSNTISELAGDSVESIPYIEQDIVKPPS-DFAD 1475
            ...:|.:...:|.|...      |....|..::|..:|   ...|.|.|.....:|.||| |:.|
Zfish  1109 GPVEGPSNPEQQLHEQEKRIEISCALAAEASRRSRLLS---AQCVPSPPASPTSLVPPPSADYTD 1170

  Fly  1476 S 1476
            |
Zfish  1171 S 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	94/460 (20%)
		PDZ	1700..1776	CDD:214570
		PH-like	1792..1893	CDD:473070
		PH-like	1911..2011	CDD:473070
plekha6	XP_073772778.1	None