Protein Alignment CG43707 and Pdzph1

DIOPT Version :10

• Sequence 1: NP_001260005.1
• Gene: CG43707 / 33601
• FlyBaseID: FBgn0263846
• Length: 2021
• Species: Drosophila melanogaster
• Sequence 2: NP_001389166.1
• Gene: Pdzph1 / 501196
• RGDID: 1560925
• Length: 1230
• Species: Rattus norvegicus
• Alignment Length: 1401
• Identity: 304/1401 - (21%)
• Similarity: 494/1401 - (35%)
• Gaps: 405/1401 - (28%)

  Fly   832 GLRLPSTPASPCRDELLANVSTYPSSDSLANDNTRDH-SDGIWNESQVTVLTAEQRDISDGSYSS 895
            |...||.||.|      .||..:       .::.:.| |:.::::::.   ..:.::..|...|:
  Rat     2 GTSQPSGPACP------KNVKDF-------EEDIKGHTSEAVFHQTRA---LGKLKESGDDYISA 50

  Fly   896 NLLLTPSSKRKNLLLQHQQRSSVDTDALDFEEQSPTYGLQTLPKIIKT--PTPTTSRP------- 951
            ::   ...:..:.|::.::::|.|.:               :||.::.  |.|..|..
  Rat    51 SI---NGKQNSSFLIKDEKKASSDNN---------------IPKRMENGYPPPVVSHQLEEVLSV 97

  Fly   952 ---TSTQPMMPPPAIAVTPSTNQILDSCISSPLPKRSMVARG--------SVPDARQLMFTSGA- 1004
               ...:..:|...      |.|...|.:....|.:....|.        .|.....:.:.:||
  Rat    98 AMFNDREKSLPGKI------TTQDFSSTVEVLKPAKGKFIREVKCGTFNVQVETTENVFYKTGAQ 156

  Fly  1005 --TKQR----HSDASFLPMGAADYARSADISECSTNTDEYATCTDTSKRTPVSTQSSQLEKTHAG 1063
              ||:|    |...|...:..|..:|.......|...::         |.| |||..::.::...
  Rat   157 FLTKRRRPTCHQHCSIQQVWRASKSRRRFSKYRSVWAED---------RVP-STQVREMSRSEVP 211

  Fly  1064 SSFESASSLYSMREDLLQHDEKERDKQTTLTKAQLKSPIGSVAELTRKSPSHSISSTTSSGSCPV 1128
            |...|...    :|.::::..||::  .::..:..|| ||..|:.:|.|.:|:.:....|.|.|.
  Rat   212 SMNISIVG----KEIVVKYVSKEQN--ISINVSHPKS-IGKSAKRSRGSLNHTTNEPCESPSQPG 269

  Fly  1129 LGAAIK------SPAKESLPQTVASSVTSQMKVSSVECIPPGVKPKPDSISEDERSEVRYSSSGY 1187
            :....|      :...||||....|..|.|.|.|.....         |:|...|.|.:..|:
  Rat   270 INLVEKQRPGNQNQNSESLPDAPCSVNTDQKKNSDTVVA---------SLSSPPRRETKKPST-- 323

  Fly  1188 YESPHEEDDEEQGTRSKARRLRQEDERKRRKTSMKLDIEKENMRALTSPIKKPTGSSKIT----- 1247
              .|....|.|:         |..|..:::...:..|              ||.|...:|
  Rat   324 --PPSAPSDSEE---------RDSDTSQQKVLQITQD--------------KPLGQHCLTADTCL 363

  Fly  1248 --SPEQSISGTMDNGSSPSKMKRFRPKIRRQLRKSS---REDVLAAAAVRRSRATPTIFGLSSGS 1307
              |.|...:.::.||.. |||.....:...:.||||   ||::.:.:.|  ...|....|..|..
  Rat   364 PPSSETLRTTSLSNGDL-SKMSFEGSRDVDEERKSSSDVRENITSESQV--PLCTAGTNGPLSAM 425

  Fly  1308 GDTELLLDASMSTGAVAGTTTSAVTSVSAPSSASK----LP----TSESSVTTQPEAVVAPLPAK 1364
            |....:.|||.|........|..:....|.|...:    ||    .|.:|:::..|......|..
  Rat   426 GGMLPVQDASESEFCPLSCLTLLLLGEKAESIGCRGDRTLPGEGYESSNSISSVSEEATKASPLL 490

  Fly  1365 KPH----SCA----TPTSLLSPKLPTTSGTQSK---------------STSDTFQLKAKSIES-- 1404
            .|.    .|:    ||.|..|........|:.:               |:::|..|:.|:..|
  Rat   491 SPSHWGTRCSKPGETPGSTFSCSQYIEFETEQEKVHYRDINKAILHGNSSANTQPLERKTPRSPA 555

  Fly  1405 LRSVSPGS------------DSVFYSEADGNAASGEQSHCHHCGK----------------EMEG 1441
            :|:.|..|            .||.:.:.:|        |.||.|:                |:|.
  Rat   556 VRTASCSSLVSKSSRRGDIRSSVEWDQTEG--------HAHHVGRAGLSRTEVPASAFLTDELEQ 612

  Fly  1442 KQQSNTISELAGDS---------VESIPYIE------------------QDI------------- 1466
            :..:....|.|.||         .|...|:|                  ||.
  Rat   613 RLTTQNYKEGAVDSNSPVAIRNPGELTSYLENVEDDTCHATAVVENACHQDFEDLTSENQNEIGS 677

  Fly  1467 -VKPPSDFADSPVTTKTTQRLYKKMDKRFRSEE--RYHGER---GRHYKTRQENIRAK------- 1518
             :|...:..:|.....||::|: .:||...|:|  ..:|:|   |.. ..|||....:
  Rat   678 QMKFAQNTTESACVGHTTEKLF-LLDKTLTSDEDPTRNGDRDICGLS-NFRQELAECQRTVSTVH 740

  Fly  1519 SEERGRIPSLPNTPVLRPAGSSPCVLPDTEQSQHIIYKGHYDAGRYTRLTDD------------- 1570
            .||.|      |......|...|..:|.:.|.|..:...:.:.....:|:.:
  Rat   741 PEESG------NERTFTEASYHPVDIPLSPQKQKALKDQNLEINNPRKLSQELALRGGRASDGSQ 799

  Fly  1571 ----DLWTQLDHQCFDRSRERRASTES----------------------------EKGFHAKYQV 1603
                |.|.:...|..|..|...|...|                            ||||:.
  Rat   800 EEAIDQWARRRQQFKDGKRCSSAGGSSVISNFTEGSVTSDDAPSVDFGFRGVDIEEKGFYT---- 860

  Fly  1604 ILHRLVQRRCTLEMYHRQKHNSFLWAKCKEISAKSFRNIFAVFTQYSGQMIELIASNSTPDSIRR 1668
                        |.:|     |..|                ||....|.      ...:|..:.:
  Rat   861 ------------ENFH-----SMAW----------------VFRGDDGN------PEDSPRCLSK 886

  Fly  1669 KLEEVLKLMLLVWARESYVISKLSNGAHGVDKTVVVKSDSGEF--GFRIHGSKPVVVAAIEPETP 1731
            |...|.       .||               :||.:...:|::  ||||..|||:||..::..:.
  Rat   887 KPRPVA-------VRE---------------RTVRLFKGTGDYPWGFRIQFSKPIVVTEVDTNSA 929

  Fly  1732 AESSGLEVGDIIISVNGVQVLDKHHTEVVKIAHDGCEKLELQVARTIGVLMHEQLEPPSQPIFSG 1796
            ||.:||::||:::||||.:|....|.|.|.:|..|.:.|.:.|...|     .:......|...|
  Rat   930 AEEAGLQIGDVVLSVNGTEVTSVEHAEAVHLAKKGPDILTMVVGSDI-----SRCPNTPWPTCRG 989

  Fly  1797 YLWRQ--SGQAKGAPNSKKWVRRWFSLRPDNCLYYYKTEDDS---QPVGAMIMAKHTVDLCPVDV 1856
            ||.::  ||..||      |.:|||.|:.|..|.|||...|.   .||..:.:....||: ...:
  Rat   990 YLHKRTHSGFVKG------WRKRWFVLKHDGFLLYYKHRKDEGKWPPVDVIKLEGAEVDI-DNSL 1047

  Fly  1857 GKPFAFKVDAGEGIPMY-VAADSDEMANRWLQLLRQAA---SQDNQWLDKSARCLYQSPSNIQRP 1917
            ||||.|......|...: :.|.|::...|||:.:::||   .|::.|.|.:|......|..|:.|
  Rat  1048 GKPFVFNCMPQSGSRTFCLCATSNQEMKRWLEAMQKAARPVRQNHVWEDVTAHNSSLPPLAIKHP 1112

  Fly  1918 DCFGYLLKLGSRWCGWSKRYCVLKDACLYFYQDANSKSAFGMACLHGYKVASMSANASGKKNSFE 1982
            :|.|.|.:|......|.:.||:|||.|||||....|..|.|...|.||.|...:...  ::...|
  Rat  1113 ECLGLLHQLERSTDVWIQHYCILKDGCLYFYASIRSTQASGGLYLQGYSVIEQTHGF--EQPVIE 1175

  Fly  1983 IVPPETKLRHYFFCTESEMDKKRWISALEYSIDRWI 2018
            :.|...:.:.::||.|::.:.:|||:||:.||.:|:
  Rat  1176 LRPSSEEFKTFYFCAENKTENQRWIAALKTSIKKWL 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	97/468 (21%)
		PDZ	1700..1776	CDD:214570	30/77 (39%)
		PH-like	1792..1893	CDD:473070	34/106 (32%)
		PH-like	1911..2011	CDD:473070	34/99 (34%)
Pdzph1	NP_001389166.1	PDZ	894..972	CDD:214570	31/92 (34%)
		PH-like	978..1085	CDD:473070	34/113 (30%)
		PH-like	1115..1207	CDD:473070	31/93 (33%)