Protein Alignment CG43707 and LOC116407614

DIOPT Version :10

• Sequence 1: NP_001260005.1
• Gene: CG43707 / 33601
• FlyBaseID: FBgn0263846
• Length: 2021
• Species: Drosophila melanogaster
• Sequence 2: XP_031749144.1
• Gene: LOC116407614 / 116407614
• XenbaseID: XB-GENE-29092819
• Length: 1301
• Species: Xenopus tropicalis
• Alignment Length: 1538
• Identity: 303/1538 - (19%)
• Similarity: 522/1538 - (33%)
• Gaps: 480/1538 - (31%)

  Fly   702 KAEIAMRK----------MQQQRMAQAAALTLPKPKSQPVEVEVRKVELEPSDEEEDEDEV---- 752
            ||::|::.          .:.:..::.:.|::.|     ...||.|.| |.:.|.:.|:|.
 Frog     4 KADVALKNPGMSVFSSLDSELENESEYSCLSMSK-----TATEVEKHE-ETAKEMQCEEETVPCE 62

  Fly   753 -------SEPEEEDDG--------------EEIDDDEQKL----ETDLQEDEEPLYENITPCGCR 792
                   |.|:|.:.|              ||..:.::::    |...|...:.|:.|:.   .|
 Frog    63 HNGLPNPSVPKESEKGVLQDVIAMSLSERNEECHNPKKQINDSDEVTAQVTSDNLHLNLE---IR 124

  Fly   793 VVPTSDA-----------------EDIQDKRSQF--RKRSVSLDDDYEAKASETPTPTGLRLPST 838
            .|.:||.                 .|.|.::||.  ..|.:|: ||...|:.|.|......:|.
 Frog   125 NVSSSDRTKVVITNKKSLKKSRSYHDSQHQQSQHNAHNRDISV-DDVNRKSQENPNKQNSEMPL- 187

  Fly   839 PASPCRDELL-ANVST-YPSSD-----SLANDNTRD----------HS-----DGIWN--ESQVT 879
                .:.|:: |.:.. |.:.|     .:..||.|.          ||     :|.|:  .|..:
 Frog   188 ----IKVEIIGAGIEVKYKTIDRHLTVHIERDNERKEREERETCYFHSNDYLQEGTWSSYSSDFS 248

  Fly   880 VLTAEQRDISD--------GSYSSNLLLTPSSKRKNLLLQHQ--QRSSVDTDALDFEEQSPTYGL 934
            ....|:...||        ..::....::|::...|..|.|.  ::|...:.......:|.|.
 Frog   249 PYQREEMICSDCCIDIPPPEEFADVKCVSPNTNVGNEALIHDLLRKSCSISSIFSSHSESETE-- 311

  Fly   935 QTLPKIIKTPTPTTSRPTSTQPMMPPPAIAVTPSTNQILDSCISS----------PLPKRSMVAR 989
                   :.|.......|...|::          .|::...|:::          |. |.|....
 Frog   312 -------RRPIKDECYKTEHMPLL----------DNRLCMPCLNNCTNCSHLTVKPY-KMSCNHI 358

  Fly   990 GSVPDARQLMFTSGATKQRHSDASFLPMGAADYARSADISECSTN------TDEYATCTDTSKRT 1048
            .|:........|||.....:.::.|     ....|.....|...|      ...:|.|.|.|...
 Frog   359 SSISPQEIHSNTSGCIHHPNQNSVF-----DSVVRRKTFPEIYYNPHIHSYNSRHANCKDHSPEQ 418

  Fly  1049 PVSTQSSQLEK--THAGSSFESASSLYSM--REDLLQHDEKERDKQTTLTKAQLKSPIGSVAELT 1109
            . ||.:|..|:  .|. .|.|...|..::  |..:..|.|.|               ..|:...:
 Frog   419 S-STSNSCTERCLNHV-PSIELRRSFTALPCRNCVNDHHEPE---------------CKSILLHS 466

  Fly  1110 RKSPSHSISSTTSS---GSCPVLGAAIKSPAKESLPQTVASSVTSQMKVSSVECIPPGVKPKPDS 1171
            .::.||.:::....   |||        |....|...|:.:.:.|...:.:::     :..|...
 Frog   467 ERAASHFVNTIEDPYFVGSC--------SDTPSSKRNTMPTDMDSVRSLHNLD-----INNKHSY 518

  Fly  1172 ISED------ERSEVRYSSSGYYESPHEED---DEEQGTRSKARRLRQEDERKRRKTSMKLDIEK 1227
            ..||      ...::.::.||:.|...:.|   :.:..:..:.:.|..:.....|.:|.:..|||
 Frog   519 EEEDTEDLKHNEDQIDFTESGFDEEMQDGDNVIETQDYSELQNKCLLIQVTPPSRSSSKEFIIEK 583

  Fly  1228 ENMRALTSPIKKPTGSSKITSPEQSISGTMDNGSSPSKMKRFRPKIRRQLRKSSREDVLAAAAVR 1292
            .....|.:           ...:.|:|.||:...|.|.:          |..|.|:        |
 Frog   584 NVYSNLPN-----------DCVQTSLSQTMEIPQSSSTV----------LEMSQRK--------R 619

  Fly  1293 RSRATPTIFGLSSGSGDTELLLDASMSTGAVAGTTTSAVTSVSAPSSASKLPTSESSVTTQPEAV 1357
            |......:      :||.|..|       .|.|...:...|||:..........:.|...|..:|
 Frog   620 RGSVVTVV------TGDLEQRL-------LVQGDNQAVSDSVSSRGYCELHKDIQQSPFVQRNSV 671

  Fly  1358 VAPLPAKKPHSCATPTSLLSPKLPTTSGTQSKSTSDTFQLKAKSIESLRSVSPGSDSVFYSEADG 1422
            :.|:                            |..|..:|:.|.:.|..
 Frog   672 LTPV----------------------------SDVDEAELENKLLSSFE---------------- 692

  Fly  1423 NAASGEQSHCHHCGKEMEGKQQSNTISELAGDSVESI-PYIEQDIVKPPSDFADSPVTTKTTQRL 1486
                               :|...|:.:::..:.:|. |::.   ::..|:|.|   |.:|..|:
 Frog   693 -------------------EQSQPTLKDISSQTSQSFDPFLS---MENQSNFED---TQETVSRV 732

  Fly  1487 YKKMDKRFRSEERYHGERGRHYKTRQENIRAKSEERGRIPSLPNTPVLRPAGSSPCVLPDTEQSQ 1551
            .:..|..|.:::                                   ..|..||...:|.|....
 Frog   733 EEGSDMNFPADD-----------------------------------TSPRNSSDSAIPGTSFES 762

  Fly  1552 HIIYKGHYDAGRYTRLTDDDLWTQLDHQCFDRSRERRASTESEKGF---HAKYQVILHRL----- 1608
                    .||:.:.|...|. .:...:|.::..:....:|:.|.|   .||.:.:...|
 Frog   763 --------IAGQLSSLKKSDS-EENGVKCVEKRDDSCEKSETPKQFAKKDAKPEFVNKHLRLPKE 818

  Fly  1609 ----VQRRCTLEMYHRQKHNSFLWAK-------CKEISAKSFRNIFAVFTQYSGQMIE------- 1655
                ..|.|  |:.|.....|..|||       .|..::....::.:..|:.||...|
 Frog   819 SVIKESRAC--EITHEGSEASDRWAKKRKQFKETKNCNSAGGSSVTSNITEESGNSEETRSVDLG 881

  Fly  1656 ---------------------LIASNSTPDSIRRKLEEVLKLMLLVWARESYVISKLSNGAHGVD 1699
                                 ....:.:||:..|                  .:||........:
 Frog   882 VRSDGKDKGLYTESFHSTSWIFRGDDCSPDNSPR------------------CLSKRPRSVAIRE 928

  Fly  1700 KTVVVKSDSGEF--GFRIHGSKPVVVAAIEPETPAESSGLEVGDIIISVNGVQVLDKHHTEVVKI 1762
            :||.:...:|::  ||||..|||::|..::....||.:||:||||:::|||..|....|:|...:
 Frog   929 RTVRIAKGTGDYPWGFRIQFSKPILVTEVDTNGAAEEAGLQVGDIVMAVNGTDVTSIPHSEAACL 993

  Fly  1763 AHD--GCEKLELQVARTIGVLMHEQLEP-----------------------------------PS 1790
            |..  .|.      .||:..::.:::.|                                   |:
 Frog   994 ARQEKSCS------YRTVLAVLSKRVSPMYGPKIGNIHQFFTFDINHGPDLLTLVVGSDISRFPT 1052

  Fly  1791 --QPIFSGYLWRQ--SGQAKGAPNSKKWVRRWFSLRPDNCLYYYKTEDDSQPVGAMIMAKHTVDL 1851
              :|...|||.::  ||..||      |.:|||.|:.|..|.|||.:.|......:.:.|.....
 Frog  1053 TPRPSCRGYLHKRTHSGLLKG------WRKRWFVLKHDGSLQYYKHKKDEGKCRPLEVTKLEGSE 1111

  Fly  1852 CPVD--VGKPFAFK-VDAGEGIPMYVAADSDEMANRWLQLLRQAA---SQDNQWLDKSARCLYQS 1910
            ..||  :||||.|| |........|..|.|::...|||:.:.:|.   :|::.|:|.:...|...
 Frog  1112 IGVDTTLGKPFVFKCVPQSANRIFYFCATSNQEMKRWLEAMDKAVHPLTQNHVWVDVTMHNLSLP 1176

  Fly  1911 PSNIQRPDCFGYLLKLGSRWCGWSKRYCVLKDACLYFYQDANSKSAFGMACLHGYKVASMSANAS 1975
            |..|:.|:|.|.|.:|......|.:.||:|||.|||||....|.||.|...|.||.|...|.|:
 Frog  1177 PLAIKNPECLGLLHQLDRNKDVWMQHYCILKDGCLYFYSSIRSTSALGGIYLQGYTVTEQSLNS- 1240

  Fly  1976 GKKNSFEIVPPETKLRHYFFCTESEMDKKRWISALEYSIDRWI 2018
             ::...|:.||..:.:.::....:..:.||||:||:.||::|:
 Frog  1241 -RRCIIELRPPSEEFKAFYLSAGNAAENKRWITALKMSINKWL 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	73/428 (17%)
		PDZ	1700..1776	CDD:214570	27/79 (34%)
		PH-like	1792..1893	CDD:473070	35/105 (33%)
		PH-like	1911..2011	CDD:473070	36/99 (36%)
LOC116407614	XP_031749144.1	PDZ_canonical	930..>990	CDD:483948	24/59 (41%)
		PH-like	1049..1155	CDD:473070	36/111 (32%)
		PH-like	1181..1274	CDD:473070	33/94 (35%)