DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10019 and SLC16A6

DIOPT Version :9

Sequence 1:	NP_001368939.1	Gene:	CG10019 / 33600	FlyBaseID:	FBgn0031568	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	XP_005257846.2	Gene:	SLC16A6 / 9120	HGNCID:	10927	Length:	527	Species:	Homo sapiens

Alignment Length:	530	Identity:	123/530 - (23%)
Similarity:	219/530 - (41%)	Gaps:	95/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 PDGGWGWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIELLGALSWSVSMVATSFVVS- 502
            |||||||.:....|.|.:.|.|:..::| ::|..:....|.|.    ..:||.:|:..  ||::
Human    23 PDGGWGWAVAVSFFFVEVFTYGIIKTFG-VFFNDLMDSFNESN----SRISWIISICV--FVLTF 80

  Fly   503 -------LCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLG 560
                   |..:...||:.::|||::..|::..||:.|...:..:.||:.|:|.......:..:|.
Human    81 SAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILS 145

  Fly   561 NYFKRRRQFVEMVAMSGEGVGIALFS---VILKEGVGKAGWRLGLQIVAALTALSFFMGLMYRPA 622
            .||.:||..|..||.:||...:..|:   :.|||   :.|||..|..|..|.......|.:.||.
Human   146 QYFGKRRSIVTAVASTGECFAVFAFAPAIMALKE---RIGWRYSLLFVGLLQLNIVIFGALLRPI 207

  Fly   623 SLYHP---------QRRAIQH-LKNQRKKMR-------------------------EKKPILSQD 652
            .:..|         .|:..|: |:|::.:..                         |.|..:.|.
Human   208 FIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDSGVELTTSPKNVPTHTNLELEPKADMQQV 272

  Fly   653 -VESTP-----KYFFLDISSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQ 711
             |:::|     |...||.|.||..:.....:....|:.|.:.|...:.......|.|......|.
Human   273 LVKTSPRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLL 337

  Fly   712 TFLGISMALGVVIAGALLRRCFVIRHFVINTKIVTQLFLSIVALAILFLS-----FVMGYTGLCI 771
            :.:.|:...|.:.||           ||:|.:.:.::::.::.:.:|.:|     |...:.||..
Human   338 STMAIAEVFGRIGAG-----------FVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMS 391

  Fly   772 LSWLYG--IG-LGGFQYSL----KILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYS 829
            .|..:|  :| :||....|    .::.:|::     |.|.|....::|:..|...||...|.|.|
Human   392 CSIFFGFMVGTIGGTHIPLLAEDDVVGIEKM-----SSAAGVYIFIQSIAGLAGPPLAGLLVDQS 451

  Fly   830 LKYGRAGYYICSAAAAISGIIIFFISEPQ----QQHQQQQQQLHHHYQQRNGHLATPTLMRHASA 890
            ..|.|| :|.|:|..|::.:.:..:...:    |.|...:.::..|..:....:....|....:.
Human   452 KIYSRA-FYSCAAGMALAAVCLALVRPCKMGLCQHHHSGETKVVSHRGKTLQDIPEDFLEMDLAK 515

  Fly   891 RQHRPHLPMD 900
            .:||.|:.|:
Human   516 NEHRVHVQME 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10019	NP_001368939.1	MFS_MCT_SLC16	444..840	CDD:340910	107/459 (23%)
SLC16A6	XP_005257846.2	2A0113	23..512	CDD:273325	119/515 (23%)
SLC16A6	XP_005257846.2	MFS	33..476	CDD:119392	108/469 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910