DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10019 and slc16a10

DIOPT Version :9

Sequence 1:	NP_001368939.1	Gene:	CG10019 / 33600	FlyBaseID:	FBgn0031568	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_001073497.1	Gene:	slc16a10 / 566499	ZFINID:	ZDB-GENE-040724-214	Length:	505	Species:	Danio rerio

Alignment Length:	549	Identity:	123/549 - (22%)
Similarity:	224/549 - (40%)	Gaps:	113/549 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 QPPPTQQQQHHHQQRAKNLMANGGCYFGYEANHHPSLHATTPHPSHITDEEDSAFPGLADREFHL 415
            :|.||.:|:...:.               |....|     ||.|   |.|.:......::.|..|
Zfish     3 EPEPTLEQEPTPEP---------------EPTQEP-----TPEP---TPEPEPTQEPESEPELEL 44

  Fly   416 LHRNIPALRRTGVDTTRI------RQYFYPDGGWGWIICGVSFLVHILTTGLQLSYGLLWFYAVQ 474
            ...|         ..|:.      .::..|:|||||::...|...:....|:|.::|:::.|.:.
Zfish    45 KQEN---------GCTKASEQKSPEEFEPPEGGWGWVVMLASMWCNGSVFGIQNAFGIMFVYLLN 100

  Fly   475 YLHNTSGIELLGALSW--SVSMVATSF---VVSL------CRKRSIRLLSIVGGLVMP-LGILFT 527
            ...:....:|....:|  |:||....|   :||:      ||      ::.|||..:. :|:|.:
Zfish   101 EFGSEHDADLRFKTAWVGSLSMGMIFFCSPIVSVFTDLLGCR------ITAVGGAAVGCVGLLAS 159

  Fly   528 SFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEG 592
            ||.|..|.:.|:|||||..|.:...:.|.|:||:|||||...|..:..:|..|.......:|...
Zfish   160 SFVTSLGPMYFTYGIVFACGCSFAYQPSLVILGHYFKRRLGLVNGIVTAGSSVFTITLPYMLSGL 224

  Fly   593 VGKAGWRLGLQIVAALTALSFFMGLMYRPASLYHPQRRAIQHLKNQRKKMREKKPILSQDVEST- 656
            :...|....|:::|....:....||.|                          ||:|.:.|.|:
Zfish   225 LKSVGLYHTLRVLAIFMFILMLAGLTY--------------------------KPLLPKPVSSSK 263

  Fly   657 ------PKYFFLDISSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQ-GSDVQELVLLQTFL 714
                  |.....:::..||:..:|.......|.:|.:.|...:..:..|: |.:..:.||| ..:
Zfish   264 PGSRCPPLSRIFNVNIWKSLGYRIWAFGIPAALYGYFVPYVHLMTHVEERFGPEANKEVLL-ACI 327

  Fly   715 GISMALGVVIAGALLRRCFVIRHFVINTKIVTQLFLSIVALAILFLSFVM--------GYTGLCI 771
            ||:..:|.:|.|.       :..:|..   |.::||.:.:..::.:..:|        |...:|:
Zfish   328 GITSGVGRLIFGR-------VADYVPG---VNKVFLQVSSFMVIGVMSMMIPLCHVFGGLIAVCL 382

  Fly   772 LSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYGRAG 836
            |..|:.   |.|...:..:|.|.:..::.|:|.||:.|:.|:|:.:..|:..||.|....|..|
Zfish   383 LMGLFD---GCFICIMAPIAFELVGSQNVSQAIGFLLGMMSIPMTVGPPIAGFLRDRLGSYDVA- 443

  Fly   837 YYICSAAAAISGIIIFFISEPQQQHQQQQ 865
            :|:......|.|.::..|...:.:.::::
Zfish   444 FYLAGIPPLIGGAVLCAIPWVEARRKRRE 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10019	NP_001368939.1	MFS_MCT_SLC16	444..840	CDD:340910	101/423 (24%)
slc16a10	NP_001073497.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		15/92 (16%)
		2A0113	56..458	CDD:273325	107/448 (24%)
		MFS	71..462	CDD:119392	102/437 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020