DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10019 and SLC16A8

DIOPT Version :9

Sequence 1:	NP_001368939.1	Gene:	CG10019 / 33600	FlyBaseID:	FBgn0031568	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_037488.2	Gene:	SLC16A8 / 23539	HGNCID:	16270	Length:	504	Species:	Homo sapiens

Alignment Length:	450	Identity:	107/450 - (23%)
Similarity:	189/450 - (42%)	Gaps:	72/450 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 PDGGWGWIICGVSFLVHILTTGLQLSYGL-----LWFYAVQ------YLHNTSGIELLGALSWSV 492
            |||||||::.|..|:|    ||  .:||.     ::|.|:.      |........::.|:.:..
Human    13 PDGGWGWVVLGACFVV----TG--FAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGT 71

  Fly   493 SMVATSFVVSL-CRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREAST 556
            ..|::..|... ||.     :.:.|||:...|::..||||...::..:.|::.|:|:|:..:.|.
Human    72 GPVSSILVTRFGCRP-----VMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSL 131

  Fly   557 VMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVAALTALSFFMGLMYRP 621
            :|||.||:|||.....:|.:|..|.::..|.:.::.:.:.|||.|..::..|.......|.:.||
Human   132 IMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRP 196

  Fly   622 ASLYHPQRRAIQHLKNQRK--------------KMREKKPILSQDVESTPKYFFLDISSLKSVTV 672
            ..  .|..|..:.....|.              ::||..|      ...|:...||::.......
Human   197 PP--GPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASP------RVRPRRRLLDLAVCTDRAF 253

  Fly   673 KILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRCFVIRH 737
            .:..:|..:.:.|::.|..|:...|.:.|....:...|.:.:|....:.....|||.....:..|
Human   254 AVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPH 318

  Fly   738 FVINTKIVTQLF-LSIVALAILFLSF--VMGYTGL---CILSWL-YGIGLGGFQYSLKILALERI 795
                   |..|| |:::|..:..||.  ...|..|   |:...| ||: :|..|:.:.:.|   :
Human   319 -------VPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGM-VGALQFEVLMAA---V 372

  Fly   796 KLKHFSKAWGFIRGVESVPVLISVP----LTSFLNDYSLKYGRAGYYICSAAAAISGIII 851
            ....|..|.|.:..||:..|||..|    |...|.:|.:.     :|:..:..|::|:.:
Human   373 GAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEII-----FYLAGSEVALAGVFM 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10019	NP_001368939.1	MFS_MCT_SLC16	444..840	CDD:340910	100/432 (23%)
SLC16A8	NP_037488.2	2A0113	1..460	CDD:273325	107/449 (24%)
		MFS	19..429	CDD:119392	101/443 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..224		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920