DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10019 and Slc16a2

DIOPT Version :9

Sequence 1:	NP_001368939.1	Gene:	CG10019 / 33600	FlyBaseID:	FBgn0031568	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_033223.2	Gene:	Slc16a2 / 20502	MGIID:	1203732	Length:	545	Species:	Mus musculus

Alignment Length:	484	Identity:	109/484 - (22%)
Similarity:	199/484 - (41%)	Gaps:	83/484 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 PDGGWGWII------CGVSFLVHILTTGLQLSYGLLWFYAV-QYLHNTSGIEL----LGALSWSV 492
            |:||:|||:      |..|..      |:..|.|:|:...: :.......:|.    :|||:..:
Mouse   101 PEGGFGWIVVFAATWCNGSIF------GIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGM 159

  Fly   493 SMVATSFVVSLCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTV 557
            ....:..|.....:...|:.:..|..|..:|:..:||.:......|:|||:||.|.:...:.|.|
Mouse   160 IFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLV 224

  Fly   558 MLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVAALT--ALSFFM----- 615
            :||:||:||......|..:|..:....|..::|        .||.:|..|.|  .||.||
Mouse   225 ILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIK--------MLGDKIKLAQTFQVLSTFMFVLTL 281

  Fly   616 -GLMYR---PASLYHPQRRAIQHLKNQRKKMREKKPILSQDVESTPKYFFLDISSLKSVTVKILL 676
             .|.||   |:|...|.:|. .|...||..::.:            |||.:.:  .:..|.:|..
Mouse   282 LSLTYRPLLPSSQDTPSKRG-AHTLRQRFLVQFR------------KYFNMRV--FRQRTYRIWA 331

  Fly   677 MTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRCFVIRHFVIN 741
            ...:.|:.|.:.|...:.....::..:::|..:|...:|.:..||.:::|          |...:
Mouse   332 FGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSG----------HISDS 386

  Fly   742 TKIVTQLFLSIVALAILFLSFVM-----GYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFS 801
            ...:.:::|.:::..:|.|..:|     .:.||.::....|:..|.|...:..:|.|.:.....|
Mouse   387 IPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQAS 451

  Fly   802 KAWGFIRGVESVPVLISVPLTSFL----NDYSLKYGRAGYYICSAAAAISGIIIFFISEPQQ--- 859
            :|.|::.|:.::|::...|:...|    .||     ...:|.......|..:|:||:....|
Mouse   452 QAIGYLLGMMALPMIAGPPIAGLLRNCFGDY-----HVAFYFAGVPPIIGAVILFFVPLMHQRMF 511

  Fly   860 ---QHQQQQQQLHHHYQQRNGHL--ATPT 883
               |....:.::..|....||.|  .:||
Mouse   512 KKEQRDSSKDKMLSHDPDPNGELLPGSPT 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10019	NP_001368939.1	MFS_MCT_SLC16	444..840	CDD:340910	94/426 (22%)
Slc16a2	NP_033223.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..98
		2 X 22 AA approximate tandem repeats	29..72
		2A0111	92..519	CDD:331689	103/461 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..545		7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020