DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10019 and SLC16A10

DIOPT Version :9

Sequence 1:	NP_001368939.1	Gene:	CG10019 / 33600	FlyBaseID:	FBgn0031568	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_061063.2	Gene:	SLC16A10 / 117247	HGNCID:	17027	Length:	515	Species:	Homo sapiens

Alignment Length:	485	Identity:	108/485 - (22%)
Similarity:	210/485 - (43%)	Gaps:	81/485 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 PDGGWGWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIELLGALSW--SVSMVATSF-- 499
            |:|||||::...:...:....|:|.:.|:|:...::...:....:::...:|  |:||....|
Human    65 PEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCC 129

  Fly   500 -VVSL------CRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTV 557
             :||:      |||     .::||..|..:|::.:||.:....:..:|||:|..|.:...:.|.|
Human   130 PIVSVFTDLFGCRK-----TAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLV 189

  Fly   558 MLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVAALTALSFFMGLMYRP- 621
            :||:|||:|...|..:..:|..|...|..::|:..:...|....|:::.....:.|..|..|||
Human   190 ILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPL 254

  Fly   622 -------------ASLYHPQRRAIQHLKNQRKKMREKKPILSQDVESTPKYFFLDISSLKSVTVK 673
                         :||:            .|||.            |.||..| :.:..|.....
Human   255 ATSTKDKESGGSGSSLF------------SRKKF------------SPPKKIF-NFAIFKVTAYA 294

  Fly   674 ILLMTSSVASFGIYTP-MFLMA-LNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRCFVIR 736
            :..:...:|.||.:.| :.||. :|...|....:|:||:  .:|::..:|.::.|.       |.
Human   295 VWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLM--CIGVTSGVGRLLFGR-------IA 350

  Fly   737 HFVINTK-----IVTQLFLSIVALAILFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIK 796
            .:|...|     :::..|:.::::.|...|.......:|::..|:.   |.|...:..:|.|.:.
Human   351 DYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFD---GCFISIMAPIAFELVG 412

  Fly   797 LKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYGRAGYYICSAAAAISGIIIFFISEPQQQH 861
            .:..|:|.||:.|..|:|:.:..|:...|.|....|..| :|:......|.|.::.||.....:.
Human   413 AQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVA-FYLAGVPPLIGGAVLCFIPWIHSKK 476

  Fly   862 QQQ------QQQLHHHYQQRNGHLATPTLM 885
            |::      ::::....:.:|..|::.:.|
Human   477 QREISKTTGKEKMEKMLENQNSLLSSSSGM 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10019	NP_001368939.1	MFS_MCT_SLC16	444..840	CDD:340910	96/427 (22%)
SLC16A10	NP_061063.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		2A0113	67..487	CDD:273325	104/462 (23%)
		MFS	71..470	CDD:119392	98/441 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020