DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNK5

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_003731.1	Gene:	KCNK5 / 8645	HGNCID:	6280	Length:	499	Species:	Homo sapiens

Alignment Length:	344	Identity:	62/344 - (18%)
Similarity:	113/344 - (32%)	Gaps:	133/344 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 ELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAP------- 400
            ::|..|.|:|.|:::...:..:...:.    ..:|.|. ||:::.:|::|:|:||...
Human   159 QITCTVIFIVWGVLVHLVIPPFVFMVT----EGWNYIE-GLYYSFITISTIGFGDFVAGVNPSAN 218

  Fly   401 -----KTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQP 460
                 :.::.:::     ..|:..::|.|...||.|...:       |..|||||.........|
Human   219 YHALYRYFVELWI-----YLGLAWLSLFVNWKVSMFVEVH-------KAIKKRRRRRKESFESSP 271

  Fly   461 ------RLPGAPGG-----------------------------VSGCGTPGSGPHSGPMGSGGTG 490
                  ::.|:...                             .||.|..|.||..||.|.|
Human   272 HSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGG--- 333

  Fly   491 PRRMNNKTKDLVSPKSVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKPTFQPRIPT--PLAATP 553
                                        :.|:.|    .|.|.:...|    .|:||  .::.|
Human   334 ----------------------------LPALPP----SLVPLVVYSK----NRVPTLEEVSQT- 361

  Fly   554 PPPVSSAGGMTASGIGTTSATGATSAPQPATPLPSIAVSTTASVG----------------KDLG 602
               :.|.|.::.|    ........||:.::|.|.:.::....:.                :|..
Human   362 ---LRSKGHVSRS----PDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDAS 419

  Fly   603 ISTTTTTA----QETSKKA 617
            |:...|.|    :||||.:
Human   420 ITFVNTEAGLSDEETSKSS 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	20/107 (19%)
		Ion_trans_2	355..429	CDD:285168	12/85 (14%)
KCNK5	NP_003731.1	Ion_trans_2	<81..137	CDD:311712
		Ion_trans_2	171..243	CDD:311712	11/81 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..335		10/53 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..388		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..499		4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000