DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and TOK1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_012442.1	Gene:	TOK1 / 853352	SGDID:	S000003629	Length:	691	Species:	Saccharomyces cerevisiae

Alignment Length:	347	Identity:	65/347 - (18%)
Similarity:	120/347 - (34%)	Gaps:	102/347 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 WQEMKPRIWSLFDEPYSS------NAAKTI----GVVSVFFICISILSF----CLKTHPDMRVPI 218
            |:.:|..  |:...|.|:      |..||:    |:.:|..|.: :|.|    .|..|...::..
Yeast   105 WRSLKNN--SVVTNPRSNDTDVLMNQVKTVFDPPGIFAVNIISL-VLGFTSNIILMLHFSKKLTY 166

  Fly   219 VR----NITVKTANGSNGWFL---------DKTQTNAHIAFFYIECVCNAWF---TFEILVRFI- 266
            ::    |||..|..|  |..|         |.....:....|:..|:.:..:   |..:.:.||
Yeast   167 LKSQLINITGWTIAG--GMLLVDVIVCSLNDMPSIYSKTIGFWFACISSGLYLVCTIILTIHFIG 229

  Fly   267 ----SSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFAS--HLENADILEFFSI-IRIMRLFKLT 324
                ..|..:..:.:..:|:.|...||.::......|:.  |:...:.|.|.:: :..:.|..:.
Yeast   230 YKLGKYPPTFNLLPNERSIMAYTVLLSLWLIWGAGMFSGLLHITYGNALYFCTVSLLTVGLGDIL 294

  Fly   325 RHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFAS-LVYYAERIQPNPHNDFN----------- 377
            ..|.|.||::..|..|...|..|:.|:...|:..:| .:::..|::......:.
Yeast   295 PKSVGAKIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGPIFFFHRVEKGRSKSWKHYMDSSKNLSE 359

  Fly   378 ---------------------------SIPLGLW------------WA--------LVTMTTVGY 395
                                       :|.:..|            |:        .:.:.|:||
Yeast   360 REAFDLMKCIRQTASRKQHWFSLSVTIAIFMAFWLLGALVFKFAENWSYFNCIYFCFLCLLTIGY 424

  Fly   396 GDMAPKTYIGMFVGALCALAGV 417
            ||.||:|..|.....:.||..|
Yeast   425 GDYAPRTGAGRAFFVIWALGAV 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	42/244 (17%)
		Ion_trans_2	355..429	CDD:285168	18/122 (15%)
TOK1	NP_012442.1	Ion_trans_2	253..328	CDD:400301	17/74 (23%)
TOK1	NP_012442.1	Ion_trans_2	388..462	CDD:400301	15/59 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
TreeFam	0	0.000	Not matched by this tool.
	1	1.000