DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcnq1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_114462.2	Gene:	Kcnq1 / 84020	RGDID:	621503	Length:	669	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	82/383 - (21%)
Similarity:	149/383 - (38%)	Gaps:	66/383 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 FYIECVCNAWFTFEILVRFISSPNK------W---EFIKSSVNIIDYIATLSFYIDLVL----QR 298
            |::|.|...:|..|.:||..|:..:      |   .|.:..::|||.|..::..:.|.:    |.
  Rat   157 FWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQV 221

  Fly   299 FASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVY 363
            ||:     ..:.....::|:|:..:.|.....::|........:||...::...||::..:..||
  Rat   222 FAT-----SAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVY 281

  Fly   364 YAER--IQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPV 426
            .||:  :..:...:|.|....|||.:||:||:||||..|:|::|..:.:..::..:...|||..:
  Rat   282 LAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGI 346

  Fly   427 IVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGT--PGSGPHSGPMGSGGT 489
            :.|.||:         |:.:|:|     ::....::|.|...:.....  ....|.|........
  Rat   347 LGSGFAL---------KVQQKQR-----QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVR 397

  Fly   490 GPRRMNNKTKDLVSPKSVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKPTFQPRIPTPLAATPP 554
            .|.|.:........||.           |::....:..||.:..|:.|:..|.    .|.....|
  Rat   398 KPARSHTLLSPSPKPKK-----------SVMVKKKKFKLDKDNGLSPGEKIFN----VPHITCDP 447

  Fly   555 PPVSSAGGMTASGIGTTSATGATSAPQPATPLPSIAVST-----TASVGKDLGISTTT 607
            |........:..|..::.....|          .:.|||     |.|..:||.:...|
  Rat   448 PEDRRPDHFSIDGYDSSVRKSPT----------LLEVSTPHFLRTNSFAEDLDLEGET 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	52/206 (25%)
		Ion_trans_2	355..429	CDD:285168	23/75 (31%)
Kcnq1	NP_114462.2	Ion_trans	123..359	CDD:395416	53/215 (25%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		Interaction with CALM. /evidence=ECO:0000250\|UniProtKB:P51787	370..382		1/11 (9%)
		KCNQ_channel	<511..617	CDD:397540
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000250\|UniProtKB:P51787	515..529
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000250\|UniProtKB:P51787	535..572
		Interaction with AKAP9. /evidence=ECO:0000250\|UniProtKB:P51787	588..616
		C-terminal assembly domain. /evidence=ECO:0000250\|UniProtKB:P51787	589..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810