DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnc4

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001182125.1	Gene:	kcnc4 / 799410	ZFINID:	ZDB-GENE-060503-773	Length:	603	Species:	Danio rerio

Alignment Length:	485	Identity:	231/485 - (47%)
Similarity:	312/485 - (64%)	Gaps:	40/485 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPIL--------NEYFFDRHPGVFA 78
            :..:::::||||.|||||::||:.||.:||:.|.:..:..:|..        :|:|||||||:||
Zfish    33 EDSDKIIINVGGTRHETYRSTLRTIPGSRLAWLADTDSQVNPDADTGQTHPNSEFFFDRHPGIFA 97

  Fly    79 QVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTE 143
            .|||||||||||.|.|||||||||||.|||:|...|||||||||.||||.:|.|.:.:..|.: :
Zfish    98 YVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFEPPDPE-D 161

  Fly   144 KPSEEELARKFGFEE--DYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSF 206
            ...::::.|:||.|:  |..:|....||   |:||:||::||||.||:.|..||:|||.:||.:|
Zfish   162 AEDDQDMPRRFGIEDSPDRSRGCCEVWQ---PKIWALFEDPYSSRAARVIAFVSLFFILVSITNF 223

  Fly   207 CLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNK 271
            ||:|| :.......:...|:|..|. ..:....|...:.  .:|.:|..|||||.|||.|..|||
Zfish   224 CLETH-EAFFEFHNHTDTKSATNST-TIIQVMDTKPVLT--VVEGICVVWFTFEFLVRIICCPNK 284

  Fly   272 WEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSI---IRIMRLFKLTRHSSGLKIL 333
            ..|||:.:||||::|.|.||::..|....|.... |:|.|..:   :||:|:||||||..||::|
Zfish   285 LLFIKNQLNIIDFVAILPFYLERSLIGNTSKAAK-DVLGFLRVVRFVRILRIFKLTRHFVGLRVL 348

  Fly   334 IQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNP-------HNDFNSIPLGLWWALVTMT 391
            ..|.|||..|..||:.||.||::|||:::||||||..:|       |..|.:||:|.|||:||||
Zfish   349 GHTLRASVNEFCLLIIFLALGVLIFATMIYYAERISADPDDPSGCNHTHFKNIPIGFWWAVVTMT 413

  Fly   392 TVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQ 456
            |:|||||.|||::||.||||||:|||||||:||||||:||.||||...|:.|||||:::..|
Zfish   414 TLGYGDMVPKTWLGMIVGALCAIAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHNP--- 475

  Fly   457 PRQPRLPGAPGGVSGCGTPGSGPHSGPMGS 486
                    .||.|...|:.|....:.|..|
Zfish   476 --------NPGMVLDSGSFGKSESNSPRNS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	63/105 (60%)
		BTB_2	27..117	CDD:280393	56/97 (58%)
		Ion_trans	244..439	CDD:278921	111/204 (54%)
		Ion_trans_2	355..429	CDD:285168	51/80 (64%)
kcnc4	NP_001182125.1	amino terminal assembly domain	1..206		88/176 (50%)
		Potassium_chann	1..29	CDD:288290
		BTB	38..144	CDD:197585	63/105 (60%)
		BTB_2	38..136	CDD:280393	56/97 (58%)
		S1-S6 membrane domain	207..516		142/307 (46%)
		Ion_trans	248..461	CDD:278921	112/215 (52%)
		Ion_trans_2	365..451	CDD:285168	55/85 (65%)
		post S6 proximal carboxyl terminal domain	517..581
		distal carboxyl terminus	582..603
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2066
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1537
OMA	1	1.010	-	-		QHG48788
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25615
orthoMCL	1	0.900	-	-		OOG6_102927
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3268
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.870