DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcnk10

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001303594.1	Gene:	Kcnk10 / 72258	MGIID:	1919508	Length:	538	Species:	Mus musculus

Alignment Length:	296	Identity:	55/296 - (18%)
Similarity:	101/296 - (34%)	Gaps:	117/296 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 IWSLFDEPYSSNAAKTIGVVSVFF----ICIS------ILSFCLKTHPDMRVPIVRNITVKTANG 229
            ::...::|:.|:...||.:....|    ||:|      ::...|.. .:..|..|.|    ::|.
Mouse    89 VFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETLIQHALDA-DNAGVSPVGN----SSNS 148

  Fly   230 SNGWFLDKTQTNAHIAFFY---------------------IECVCNAWFTFEILVRFISSPNKWE 273
            |:.|.|..       |||:                     |.|:..|.|...:          :.
Mouse   149 SSHWDLGS-------AFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPL----------FG 196

  Fly   274 FIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFR 338
            |:.:.:.  |.:.|:          |..           ||.|:.::|:..:.|.....:|.|
Mouse   197 FLLAGIG--DQLGTI----------FGK-----------SIARVEKVFRKKQVSQTKIRVIST-- 236

  Fly   339 ASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIP-----LGLWWALVTMTTVGYGDM 398
                     :.|::.|.::|.::          |...|..|.     ..:::.:||:||||:||.
Mouse   237 ---------ILFILAGCIVFVTI----------PAVIFKYIEGWTALESIYFVVVTLTTVGFGDF 282

  Fly   399 A--------------PKTYIGMFVGALCALAGVLTI 420
            .              |..:..:.|| |...|.||::
Mouse   283 VAGGNAGINYREWYKPLVWFWILVG-LAYFAAVLSM 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	39/217 (18%)
		Ion_trans_2	355..429	CDD:285168	19/85 (22%)
Kcnk10	NP_001303594.1	Ion_trans_2	<152..206	CDD:369572	11/72 (15%)
Kcnk10	NP_001303594.1	Ion_trans_2	244..323	CDD:369572	19/85 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000