DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcns2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_076456.1	Gene:	Kcns2 / 66022	RGDID:	621525	Length:	477	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	137/427 - (32%)
Similarity:	222/427 - (51%)	Gaps:	38/427 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVF 77
            |.|.|:  ||||.:......||.:.|.|||.||         .|...:||.:..|::|||:|.:|
  Rat    16 DGEIRI--NVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78

  Fly    78 AQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDT 142
            ..||::|.|||||...::|...|.:|:|:||::...::.||..:|...:...|.....::.|.::
  Rat    79 PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQES 143

  Fly   143 EKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFC 207
            ...|.:|:   ..|..|..|.........:.::|...|.|..|..::...|:|:..:..||::.|
  Rat   144 TTSSFDEI---LAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMC 205

  Fly   208 LKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKW 272
            |.:.||.::|        .:.|:.|         ....|..:|....||||||::.||..:|:..
  Rat   206 LNSLPDFQIP--------DSQGNPG---------EDPRFEIVEHFGIAWFTFELVARFAVAPDFL 253

  Fly   273 EFIKSSVNIIDYIATLSFYIDLVLQ---RFASHLEN-ADILEFFSIIRIMRLFKLTRHSSGLKIL 333
            :|.|:::|:||.::.:.|||.||:.   ..:..|.| ..:.:...::||.|:.||.|||:||:.|
  Rat   254 KFFKNALNLIDLMSIVPFYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSL 318

  Fly   334 IQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDM 398
            ..|.:.|.||:.||:.:|.:||.||:.:.|   .|:...:....:||...|||.|:||||||||:
  Rat   319 GATLKYSYKEVGLLLLYLSVGISIFSVVAY---TIEKEENEGLATIPACWWWATVSMTTVGYGDV 380

  Fly   399 APKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            .|.|..|....:.|.|||:|.:.||:.:|.:.|:.:|
  Rat   381 VPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFY 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	38/106 (36%)
		BTB_2	27..117	CDD:280393	35/98 (36%)
		Ion_trans	244..439	CDD:278921	74/196 (38%)
		Ion_trans_2	355..429	CDD:285168	30/73 (41%)
Kcns2	NP_076456.1	BTB_POZ_KCNS2	18..124	CDD:349734	39/107 (36%)
		Ion_trans	186..421	CDD:395416	85/252 (34%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	374..379		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820