DRSC - DRSC Integrative Ortholog Prediction Tool

DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shaw and Kcnd2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_113918.2	Gene:	Kcnd2 / 65180	RGDID:	68393	Length:	630	Species:	Rattus norvegicus

Alignment Length:		Identity:	/ - (0%)
Similarity:	/ - (0%)	Gaps:	/ - (0%)

- Green bases have known domain annotations that are detailed below.

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921
		Ion_trans_2	355..429	CDD:285168
Kcnd2	NP_113918.2	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000305\|PubMed:14980206, ECO:0000305\|PubMed:14980207	2..20
		BTB_POZ	6..144	CDD:365784
		Interaction with KCNIP1. /evidence=ECO:0000305\|PubMed:14980207	71..90
		Ion_trans	184..415	CDD:366146
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	308..321
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375
		DUF3399	445..546	CDD:371777
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000305\|PubMed:16820361	474..630
		Required for dendritic targeting. /evidence=ECO:0000269\|PubMed:12592409	474..489
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	600..623
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11923279, ECO:0000269\|PubMed:14559911	627..630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910

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