DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcnv1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_067729.1	Gene:	Kcnv1 / 60326	RGDID:	621264	Length:	503	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	144/434 - (33%)
Similarity:	229/434 - (52%)	Gaps:	64/434 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANY-------------------DPILNEYFFDR 72
            :.:||||.|....:..|...|.|||.:|...:|:|                   :|:.|||||||
  Rat    44 LTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRLGALAAAPSPLELCDDANPVDNEYFFDR 108

  Fly    73 HPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDR 137
            ....|..||:|||||:||....:|...|.:|:::||:|...::.||...|.:.::..|||..  :
  Rat   109 SSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDF--K 171

  Fly   138 LDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICIS 202
            .|.|.::...|.       |:|:.:|..   ..::.::|.:.::|.||.||:..||:|:.|:.:|
  Rat   172 KDTDDQESQHES-------EQDFSQGPC---PTVRQKLWDILEKPGSSTAARIFGVISIIFVAVS 226

  Fly   203 ILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFIS 267
            |:                |:.:.:|..|  |.      |..: ...:|.||.:|||.|.::||:.
  Rat   227 IV----------------NMALMSAELS--WL------NLQL-LEILEYVCISWFTGEFILRFLC 266

  Fly   268 SPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFA-SH----LENAD-ILEFFSIIRIMRLFKLTRH 326
            ..::..|::...||||.:|.|.|||.|:::..: ||    |||.. :::...::|.:|:.||.||
  Rat   267 VKDRCHFLRKVPNIIDLLAILPFYITLLVESLSGSHTTQELENVGRLVQVLRLLRALRMLKLGRH 331

  Fly   327 SSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMT 391
            |:||:.|..|.....:|:.||:.||.:||.||:::.|:||  |..|...|.|:|...|||..:||
  Rat   332 STGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTIEYFAE--QSIPDTTFTSVPCAWWWATTSMT 394

  Fly   392 TVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            ||||||:.|.|..|..|..:|.|:|:|.:|||:.:|...|:..|
  Rat   395 TVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACY 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	40/116 (34%)
		BTB_2	27..117	CDD:280393	37/108 (34%)
		Ion_trans	244..439	CDD:278921	78/198 (39%)
		Ion_trans_2	355..429	CDD:285168	34/73 (47%)
Kcnv1	NP_067729.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		BTB_POZ	44..163	CDD:365784	40/118 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..192		6/27 (22%)
		Ion_trans	212..438	CDD:395416	89/252 (35%)
		Selectivity filter. /evidence=ECO:0000250	395..400		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820